Reactome | sinh-1 [cytosol]

sinh-1 [cytosol]

Stable Identifier

R-CEL-3006620

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

MAPKAP1, Q9NA80

Locations in the PathwayBrowser

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Cellular responses to stimuli (Caenorhabditis elegans)

- Cellular responses to mechanical stimuli (Caenorhabditis elegans)
  - Response of endothelial cells to shear stress (Caenorhabditis elegans)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Caenorhabditis elegans)
      - mTORC2 phosphorylates AKT1 on serine-473 (Caenorhabditis elegans)
        
        mTORC2:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        MAPKAP1:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        sinh-1 [cytosol] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - Regulation of TP53 Activity (Caenorhabditis elegans)
        
        Regulation of TP53 Expression and Degradation (Caenorhabditis elegans)
        
        Regulation of TP53 Degradation (Caenorhabditis elegans)
        
        mTORC2 phosphorylates SGK1 (Caenorhabditis elegans)
        
        mTORC2:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        MAPKAP1:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        sinh-1 [cytosol] (Caenorhabditis elegans)

Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Regulation of T cell activation by CD28 family (Caenorhabditis elegans)
    - Co-stimulation by CD28 (Caenorhabditis elegans)
      - CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)
        
        mTORC2 phosphorylates AKT at S473 (Caenorhabditis elegans)
        
        mTORC2:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        MAPKAP1:PIP3 [plasma membrane] (Caenorhabditis elegans)
        
        sinh-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9NA80

Gene Names

sinh-1

Reference Genes

BioGPS Gene:190339 sinh-1

ENSEMBL:WBGene00013261

KEGG:cel:CELE_Y57A10A.20 sinh-1

Monarch:190339 sinh-1

NCBI Gene:190339 sinh-1

UCSC:Q9NA80 sinh-1

Wormbase:WBGene00013261

Wormbase:WBGene00013261 sinh-1

Reference Transcript

RefSeq:NM_064195.5 sinh-1

Other Identifiers

190339

GO:0005546

GO:0005737

GO:0005886

GO:0031932

GO:0038203

GO:0048382

GO:0048856

Participates

as a component of

MAPKAP1:PIP3 [plasma membrane] (Caenorhabditis elegans)

Inferred From

MAPKAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_496596.3

ENSEMBL

Y57A10A.20.1, WBGene00013261, Y57A10A.20.1

PRO

Q9NA80

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