Reactome | vab-2 [plasma membrane]

vab-2 [plasma membrane]

Stable Identifier

R-CEL-2682324

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

EFNA3, G5EEE7

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - EPH-Ephrin signaling (Caenorhabditis elegans)
      - EPH receptors autophosphorylate (Caenorhabditis elegans)
        
        EPH-ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
      - EPH-ephrin mediated repulsion of cells (Caenorhabditis elegans)
        
        SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHs bind VAV2,3 (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
      - EPH:EFN dimers tetramerise (Caenorhabditis elegans)
        
        EPH-EFN dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
      - EPH:EFN tetramers oligomerise (Caenorhabditis elegans)
        
        EPH-EFN dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        EPH-ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
      - EPHA-mediated growth cone collapse (Caenorhabditis elegans)
        
        NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
      - EPHAs bind EFNAs (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)
        
        vab-2 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EEE7

Gene Names

vab-2

Reference Genes

BioGPS Gene:177140 vab-2

CTD Gene:177140 vab-2

ENSEMBL:WBGene00006869

Monarch:177140 vab-2

NCBI Gene:177140 vab-2

UCSC:G5EEE7 vab-2

Wormbase:WBGene00006869

Wormbase:WBGene00006869 vab-2

Reference Transcript

RefSeq:NM_068011.4 vab-2

Other Identifiers

177140

GO:0005886

GO:0007411

GO:0009897

GO:0016020

GO:0030424

GO:0046875

GO:0048013

GO:0048730

Participates

as a member of

Homologues of EFNA3 [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

phospho-vab-2 [plasma membrane]

vab-2 [plasma membrane]

Inferred From

EFNA3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_500412.1

ENSEMBL

Y37E11AR.6a.1, Y37E11AR.6a.1, WBGene00006869

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