Reactome | efn-4 [plasma membrane]

efn-4 [plasma membrane]

Stable Identifier

R-CEL-2682320-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

EFNA2, O44516

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - EPH-Ephrin signaling (Caenorhabditis elegans)
      - EPH receptors autophosphorylate (Caenorhabditis elegans)
        
        EPH-ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
      - EPH-ephrin mediated repulsion of cells (Caenorhabditis elegans)
        
        EPHA binds TIAM1 (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHs bind VAV2,3 (Caenorhabditis elegans)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Caenorhabditis elegans)
        
        p-EPH:ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
      - EPH:EFN dimers tetramerise (Caenorhabditis elegans)
        
        EPH-EFN dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
      - EPH:EFN tetramers oligomerise (Caenorhabditis elegans)
        
        EPH-EFN dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA dimers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        EPH-ephrin oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
      - EPHA-mediated growth cone collapse (Caenorhabditis elegans)
        
        NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Caenorhabditis elegans)
        
        p-EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
      - EPHAs bind EFNAs (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)
        
        EPHAs:EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        EFNAs [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)
        
        efn-4 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O44516

Gene Names

efn-4

Reference Genes

BioGPS Gene:176882 efn-4

CTD Gene:176882 efn-4

ENSEMBL:WBGene00001165

Monarch:176882 efn-4

NCBI Gene:176882 efn-4

UCSC:O44516 efn-4

Wormbase:WBGene00001165

Reference Transcript

RefSeq:NM_067546.4 efn-4

Other Identifiers

175497_at

176882

18539097

185839_at

A_12_P114164

CE29503

CE_WBGene00001165_A

CE_WBGene00001165_B

CE_WBGene00001165_C

CGZ0024440

F56A11.3

F56A11.3_383-442_0.914_9_C

F56A11.3_727-786_0.937_2_B

F56A11.3_832-891_0.948_1_A

F56A11_3P00245

F56A11_3P00403

F56A11_3P00838

GO:0016020

WBGene00001165

cea2.c.29164

Participates

as a member of

Homologues of EFNA2 [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

phospho-efn-4 [plasma membrane]

efn-4 [plasma membrane]

Inferred From

EFNA2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_499947.1

PRO

O44516

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