Reactome | lin-53 [nucleoplasm]

lin-53 [nucleoplasm]

Stable Identifier

R-CEL-212223

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

RBBP4, P90916

Locations in the PathwayBrowser

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Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - Regulation of TP53 Activity (Caenorhabditis elegans)
        
        Regulation of TP53 Activity through Acetylation (Caenorhabditis elegans)
        
        MTA2-NuRD complex deacetylates TP53 (Caenorhabditis elegans)
        
        MTA2-NuRD complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RBBP4 [nucleoplasm] (Caenorhabditis elegans)
        
        lin-53 [nucleoplasm] (Caenorhabditis elegans)
        
        lin-53 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - PIP3 activates AKT signaling (Caenorhabditis elegans)
    - PTEN Regulation (Caenorhabditis elegans)
      - Regulation of PTEN gene transcription (Caenorhabditis elegans)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Caenorhabditis elegans)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Caenorhabditis elegans)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Caenorhabditis elegans)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Caenorhabditis elegans)
        
        PRC2 (EZH2) Core [nucleoplasm] (Caenorhabditis elegans)
        
        RBBP4,7 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RBBP4 [nucleoplasm] (Caenorhabditis elegans)
        
        lin-53 [nucleoplasm] (Caenorhabditis elegans)
        
        lin-53 [nucleoplasm] (Caenorhabditis elegans)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Caenorhabditis elegans)
        
        PRC2 (EZH2) Core [nucleoplasm] (Caenorhabditis elegans)
        
        RBBP4,7 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RBBP4 [nucleoplasm] (Caenorhabditis elegans)
        
        lin-53 [nucleoplasm] (Caenorhabditis elegans)
        
        lin-53 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P90916

Gene Names

lin-53

Reference Genes

BioGPS Gene:172802 lin-53

ENSEMBL:WBGene00003036

Monarch:172802 lin-53

NCBI Gene:172802 lin-53

UCSC:P90916 lin-53

Wormbase:WBGene00003036

Reference Transcript

RefSeq:NM_060151.6 lin-53

Other Identifiers

172802

173503_at

18471462

193888_s_at

A_12_P114343

CE16234

CE_WBGene00003036_A

CE_WBGene00003036_C

CGZ0028091

GO:0005515

K07A1.12

K07A1.12_631-690_0.920_6_B

K07A1.12_855-914_0.911_8_C

K07A1.12_859-918_0.931_4_A

K07A1_12P00073

K07A1_12P00445

K07A1_12P01109

WBGene00003036

cea2.c.04952

Participates

as a member of

as a component of

as an input of

RBBP7 binds histone H3 (Caenorhabditis elegans)

Inferred From

RBBP7 [nucleoplasm] (Homo sapiens)

RBBP4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_492552.1

PRO

P90916

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q23482	1	lin-37 [nucleoplasm] (R-CEL-389101)	0.621	5
UniProt:Q21484	1	hat-1 [nucleoplasm] (R-CEL-3662337)	0.553	2
UniProt:O61907	3	lin-40 [nucleoplasm] (R-CEL-3465550) lin-40 [nucleoplasm] (R-CEL-4657009) lin-40 [nucleoplasm] (R-CEL-4657013)	0.553	2