Reactome | phospho-flor-1 [plasma membrane]

phospho-flor-1 [plasma membrane]

Stable Identifier

R-CEL-205207-6

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

p-7Y-KIT, O18008

Locations in the PathwayBrowser

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Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - PIP3 activates AKT signaling (Caenorhabditis elegans)
    - Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
        
        PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
        
        Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Caenorhabditis elegans)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        phospho-flor-1 [plasma membrane] (Caenorhabditis elegans)
    - PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
      - Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Caenorhabditis elegans)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        phospho-flor-1 [plasma membrane] (Caenorhabditis elegans)
- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
        
        RAS GEFs [plasma membrane] (Caenorhabditis elegans)
        
        GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        phospho-flor-1 [plasma membrane] (Caenorhabditis elegans)
- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by SCF-KIT (Caenorhabditis elegans)
    - Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)
      - GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        phospho-flor-1 [plasma membrane] (Caenorhabditis elegans)
    - Regulation of KIT signaling (Caenorhabditis elegans)
      - Recruitment of CBL to KIT (Caenorhabditis elegans)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Caenorhabditis elegans)
        
        GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        phospho-flor-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRB2:SOS1:p-KIT complex [plasma membrane] (Caenorhabditis elegans)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        phospho-flor-1 [plasma membrane] (Caenorhabditis elegans)
    - Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)
      - PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Caenorhabditis elegans)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)
        
        phospho-flor-1 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O18008

Gene Names

flor-1

Reference Genes

BioGPS Gene:180021 flor-1

CTD Gene:180021 flor-1

ENSEMBL:WBGene00011339

KEGG:cel:CELE_T01G5.1 flor-1

Monarch:180021 flor-1

NCBI Gene:180021 flor-1

UCSC:O18008 flor-1

Wormbase:WBGene00011339

Wormbase:WBGene00011339 flor-1

Reference Transcript

RefSeq:NM_074327.4 flor-1

Other Identifiers

180021

GO:0003824

GO:0004672

GO:0004714

GO:0005524

GO:0005886

GO:0006468

GO:0007169

GO:0016020

GO:0016301

GO:0016740

GO:0043235

GO:0140096

Participates

as a member of

Homologues of p-7Y-KIT [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

phospho-flor-1 [plasma membrane]

flor-1 [plasma membrane]

phospho-flor-1 [plasma membrane]

flor-1 [plasma membrane]

phospho-flor-1 [plasma membrane]

flor-1 [plasma membrane]

Inferred From

p-7Y-KIT [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 568 (in Homo sapiens)

Coordinate

568

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 570 (in Homo sapiens)

Coordinate

570

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 703 (in Homo sapiens)

Coordinate

703

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 721 (in Homo sapiens)

Coordinate

721

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 730 (in Homo sapiens)

Coordinate

730

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 823 (in Homo sapiens)

Coordinate

823

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 936 (in Homo sapiens)

Coordinate

936

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_506728.2

ENSEMBL

T01G5.1.1, T01G5.1.1, WBGene00011339

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