Reactome | iff-1 [cytosol]

iff-1 [cytosol]

Stable Identifier

R-CEL-204650

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Hyp-K50-EIF5A2, P34563

Locations in the PathwayBrowser

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Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
    - Hypusine synthesis from eIF5A-lysine (Caenorhabditis elegans)
      - DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
        
        Hyp-K50-EIF5A [cytosol] (Caenorhabditis elegans)
        
        Homologues of Hyp-K50-EIF5A2 [cytosol] (Caenorhabditis elegans)
        
        iff-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P34563

Gene Names

iff-1

Reference Genes

BioGPS Gene:176373 iff-1

CTD Gene:176373 iff-1

ENSEMBL:WBGene00002064

KEGG:cel:CELE_T05G5.10 iff-1

Monarch:176373 iff-1

NCBI Gene:176373 iff-1

UCSC:P34563 iff-1

Wormbase:WBGene00002064

Wormbase:WBGene00002064 iff-1

Reference Transcript

Other Identifiers

176373

GO:0003723

GO:0003743

GO:0003746

GO:0005515

GO:0005737

GO:0006412

GO:0006413

GO:0006414

GO:0007276

GO:0008104

GO:0022414

GO:0043022

GO:0045901

GO:0045905

Participates

as a member of

Homologues of Hyp-K50-EIF5A2 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

iff-1 [cytosol]

Inferred From

Hyp-K50-EIF5A2 [cytosol] (Homo sapiens)

Modified Residues

Name

hypusine at 50 (in Homo sapiens)

Coordinate

PsiMod Name

hypusine [MOD:00125]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.

Cross References

RefSeq

NP_001255020.1, NP_001255021.1

ENSEMBL

WBGene00002064, T05G5.10b.1, T05G5.10b.1

PRO

P34563

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