Reactome | arx-1 [cytosol]

arx-1 [cytosol]

Stable Identifier

R-CEL-200811

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

ACTR3, Q9N4I0

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - EPH-Ephrin signaling (Caenorhabditis elegans)
      - EPHB-mediated forward signaling (Caenorhabditis elegans)
        
        N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)

Immune System (Caenorhabditis elegans)

- Innate Immune System (Caenorhabditis elegans)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
    - Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
      - Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        Mother filament:branching complex:daughter filament [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
      - Detachment of WASP/WAVE (Caenorhabditis elegans)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
  - Signaling by Rho GTPases (Caenorhabditis elegans)
    - RHO GTPase Effectors (Caenorhabditis elegans)
      - RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        Mother filament:branching complex:daughter filament [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        Detachment of WASP/WAVE (Caenorhabditis elegans)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
        
        Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
        
        ARP2/3 complex (ATP bound) [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        ARP2/3 complex [cytosol] (Caenorhabditis elegans)
        
        ACTR3:ATP [cytosol] (Caenorhabditis elegans)
        
        arx-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9N4I0

Gene Names

arx-1

Reference Genes

BioGPS Gene:171857 arx-1

ENSEMBL:WBGene00000199

KEGG:cel:CELE_Y71F9AL.16 arx-1

Monarch:171857 arx-1

NCBI Gene:171857 arx-1

UCSC:Q9N4I0 arx-1

Wormbase:WBGene00000199

Wormbase:WBGene00000199 arx-1

Reference Transcript

RefSeq:NM_058665.8 arx-1

Other Identifiers

171857

GO:0000166

GO:0003779

GO:0005524

GO:0005737

GO:0005856

GO:0005885

GO:0007369

GO:0008092

GO:0010631

GO:0016331

GO:0031252

GO:0034314

GO:0048870

GO:0051015

Participates

as a component of

ACTR3:ATP [cytosol] (Caenorhabditis elegans)

Inferred From

ACTR3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_491066.1

ENSEMBL

Y71F9AL.16.1, Y71F9AL.16.1, WBGene00000199

PRO

Q9N4I0

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