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nck-1 [cytosol]
Stable Identifier
R-CEL-197954
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
NCK1, Q95PX0
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Caenorhabditis elegans)
Nephrin family interactions (Caenorhabditis elegans)
Nephrin binds NCK (Caenorhabditis elegans)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
Netrin-1 signaling (Caenorhabditis elegans)
DCC mediated attractive signaling (Caenorhabditis elegans)
Activation of Cdc42 (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Activation of Rac1 (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
DCC interacting NCK-1 (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
RhoGTPase GEF's recruited to DCC (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Interferon Signaling (Caenorhabditis elegans)
Antimicrobial mechanism of IFN-stimulated genes (Caenorhabditis elegans)
PKR-mediated signaling (Caenorhabditis elegans)
NCK1 binds PKR (Caenorhabditis elegans)
EIF2AK2:NCK1 [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
Nck binds to the active PDGF receptor (Caenorhabditis elegans)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
CDC42:GTP binds PAK2 (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
FYN autophosphorylates (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
FYN phosphorylates PAK2 (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
PAK2 autophorylates (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
PAK2 binds NCK (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
p-Y420-FYN is phosphorylated on S21 (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
p38 MAPK activation by VEGFR (Caenorhabditis elegans)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase Effectors (Caenorhabditis elegans)
RHO GTPases Activate WASPs and WAVEs (Caenorhabditis elegans)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:branching complex [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
WAVE2, WASP, N-WASP [plasma membrane] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Caenorhabditis elegans)
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
RHOV GTPase cycle (Caenorhabditis elegans)
RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)
RHOV effectors [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
RHOV:GTP:RHOV effectors [plasma membrane] (Caenorhabditis elegans)
RHOV effectors [cytosol] (Caenorhabditis elegans)
nck-1 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q95PX0
Gene Names
nck-1
Reference Genes
BioGPS Gene:180690 nck-1
CTD Gene:180690 nck-1
ENSEMBL:WBGene00006410
KEGG:cel:CELE_ZK470.5 nck-1
Monarch:180690 nck-1
NCBI Gene:180690 nck-1
UCSC:Q95PX0 nck-1
Wormbase:WBGene00006410
Wormbase:WBGene00006410 nck-1
Reference Transcript
RefSeq:NM_001375010.1 nck-1
Other Identifiers
180690
GO:0005515
GO:0005634
GO:0005737
GO:0016301
GO:0016477
GO:0030971
GO:0035591
GO:0036493
GO:0048013
GO:0048870
GO:0060090
GO:1902237
GO:1903898
Participates
as a candidate of
RHOV effectors [cytosol] (Caenorhabditis elegans)
as an input of
Nephrin binds NCK (Caenorhabditis elegans)
Nck binds to the active PDGF receptor (Caenorhabditis elegans)
NCK1 binds PKR (Caenorhabditis elegans)
DCC interacting NCK-1 (Caenorhabditis elegans)
as a component of
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Caenorhabditis elegans)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Caenorhabditis elegans)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
EIF2AK2:NCK1 [cytosol] (Caenorhabditis elegans)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
as a member of
SH3 domain proteins [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
nck-1 [cytosol]
Inferred From
NCK1,NCK2 [cytosol]
(Homo sapiens)
NCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001361996.1
ENSEMBL
WBGene00006410
,
ZK470.5b.1
,
ZK470.5b.1
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