Reactome | sel-1 [endoplasmic reticulum membrane]

sel-1 [endoplasmic reticulum membrane]

Stable Identifier

R-CEL-1911545

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

endoplasmic reticulum membrane

Synonyms

SEL1L, G5EFG0

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Adaptive Immune System (Caenorhabditis elegans)
  - Regulation of T cell activation by CD28 family (Caenorhabditis elegans)
    - Co-inhibition by PD-1 (Caenorhabditis elegans)
      - Regulation of PD-L1(CD274) expression (Caenorhabditis elegans)
        
        Regulation of PD-L1(CD274) Post-translational modification (Caenorhabditis elegans)
        
        AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) (Caenorhabditis elegans)
        
        Ubiquitination of CD274 by ERAD complex (Caenorhabditis elegans)
        
        ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        sel-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        Poly-Ub-p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        sel-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        p-S195-CD274:ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        ERAD complex [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        sel-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Hedgehog (Caenorhabditis elegans)
  - Hedgehog ligand biogenesis (Caenorhabditis elegans)
    - SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)
      - C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        sel-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
      - ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Caenorhabditis elegans)
        
        sel-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EFG0

Gene Names

sel-1

Reference Genes

BioGPS Gene:179720 sel-1

ENSEMBL:WBGene00004759

KEGG:cel:CELE_F45D3.5 sel-1

Monarch:179720 sel-1

NCBI Gene:179720 sel-1

UCSC:G5EFG0 sel-1

Wormbase:WBGene00004759

Wormbase:WBGene00004759 sel-1

Reference Transcript

RefSeq:NM_073743.8 sel-1

Other Identifiers

179720

GO:0000836

GO:0003824

GO:0004842

GO:0005515

GO:0005789

GO:0016020

GO:0016740

GO:0030163

GO:0031410

GO:0036498

GO:0036503

GO:0045746

GO:0140096

Participates

as a component of

Inferred From

SEL1L [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

RefSeq

NP_506144.1

ENSEMBL

F45D3.5.1, WBGene00004759, F45D3.5.1