Reactome | apb-1 [plasma membrane]

apb-1 [plasma membrane]

Stable Identifier

R-CEL-167690

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

AP2B1, Q9N4F3

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - Clathrin recruits PIK3C2A (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
        
        Clathrin:AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 complex [plasma membrane] (Caenorhabditis elegans)
        
        apb-1 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9N4F3

Gene Names

apb-1

Reference Genes

BioGPS Gene:175376 apb-1

CTD Gene:175376 apb-1

ENSEMBL:WBGene00000160

KEGG:cel:CELE_Y71H2B.10 apb-1

Monarch:175376 apb-1

NCBI Gene:175376 apb-1

UCSC:Q9N4F3 apb-1

Wormbase:WBGene00000160

Wormbase:WBGene00000160 apb-1

Reference Transcript

RefSeq:NM_001027766.5 apb-1

Other Identifiers

175376

GO:0005515

GO:0005737

GO:0006886

GO:0006898

GO:0009792

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030131

GO:0030276

GO:0048856

Participates

as a component of

AP-2 complex [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

apb-1 [cytoplasmic vesicle membrane]

apb-1 [Golgi membrane]

apb-1 [lysosomal membrane]

apb-1 [trans-Golgi network membrane]

apb-1 [endolysosome membrane]

apb-1 [cytosol]

apb-1 [clathrin-coated endocytic vesicle membrane]

apb-1 [cytosol]

Inferred From

AP2B1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001022937.1

ENSEMBL

Y71H2B.10.1, WBGene00000160, Y71H2B.10.1

Cite Us!