Reactome | sptf-3 [nucleoplasm]

sptf-3 [nucleoplasm]

Stable Identifier

R-CEL-1592223-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

SP1, Q9XW26

Locations in the PathwayBrowser

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Cell-Cell communication (Caenorhabditis elegans)

- Cell junction organization (Caenorhabditis elegans)
  - Cell-cell junction organization (Caenorhabditis elegans)
    - Adherens junctions interactions (Caenorhabditis elegans)
      - Regulation of Homotypic Cell-Cell Adhesion (Caenorhabditis elegans)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Caenorhabditis elegans)
        
        Regulation of CDH11 Expression and Function (Caenorhabditis elegans)
        
        Regulation of CDH11 gene transcription (Caenorhabditis elegans)
        
        ZEB2 binds SP1 (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
        
        ZEB2:SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
        
        SMAD2/3:SMAD4 heterotrimer binds SP1 (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
        
        p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
  - RNA polymerase II transcribes snRNA genes (Caenorhabditis elegans)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
    - Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Caenorhabditis elegans)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by TGFB family members (Caenorhabditis elegans)
  - Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Caenorhabditis elegans)
        
        SMAD2/3:SMAD4 heterotrimer binds SP1 (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)
        
        p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)
        
        sptf-3 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XW26

Gene Names

sptf-3

Reference Genes

BioGPS Gene:189783 sptf-3

CTD Gene:189783 sptf-3

ENSEMBL:WBGene00012735

KEGG:cel:CELE_Y40B1A.4 sptf-3

Monarch:189783 sptf-3

NCBI Gene:189783 sptf-3

UCSC:Q9XW26 sptf-3

Wormbase:WBGene00012735

Wormbase:WBGene00012735 sptf-3

Reference Transcript

RefSeq:NM_060952.6 sptf-3

Other Identifiers

189783

GO:0000978

GO:0000981

GO:0002119

GO:0003682

GO:0005634

GO:0006355

GO:0006357

GO:0008270

GO:0009887

GO:0014019

GO:0043065

GO:0045944

GO:0046872

GO:0048856

GO:0055059

Participates

as a member of

Homologues of SP1 [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

sptf-3 [nucleoplasm]

Inferred From

SP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_493353.3

ENSEMBL

Y40B1A.4.1, Y40B1A.4.1, WBGene00012735

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