Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
KEAP1 [cytosol]
Stable Identifier
R-BTA-976038
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
KEAP1, A7MBG4
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
CUL3:RBX1 ubiquitinates KEAP1 (Bos taurus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Bos taurus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Bos taurus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Bos taurus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Neddylation (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
RBX1:CUL3:BTB [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Bos taurus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
KEAP1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A7MBG4
Gene Names
KEAP1
Reference Genes
BioGPS Gene:532791 KEAP1
ENSEMBL:ENSBTAG00000003543.5
KEGG Gene (Bos taurus):532791 KEAP1
Monarch:532791 KEAP1
NCBI Gene:532791 KEAP1
Reference Transcript
RefSeq:XM_005208764.2 KEAP1
RefSeq:NM_001101142.1 KEAP1
RefSeq:XM_015472010.1 KEAP1
Other Identifiers
532791
GO:0001701
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0006351
GO:0006355
GO:0006511
GO:0006914
GO:0008152
GO:0010506
GO:0016234
GO:0016567
GO:0030154
GO:0030163
GO:0030496
GO:0031463
GO:0032991
GO:0034451
GO:0034599
GO:0036211
GO:0042802
GO:0043226
GO:0045604
GO:0048856
GO:0060090
GO:0061629
GO:0070887
GO:0071353
GO:0097718
GO:1990756
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Bos taurus)
BTB proteins [cytosol] (Bos taurus)
as a component of
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Bos taurus)
Other forms of this molecule
KEAP1 [cytosol]
KEAP1 [cytosol]
Inferred From
KEAP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005208821.1
,
XP_015327496.1
,
NP_001094612.1
OpenTargets
ENSG00000079999
Ensembl
ENSBTAP00000004604
,
ENSBTAG00000003543
,
ENSBTAT00000004604
VGNC
30537
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text