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SKP2 [nucleoplasm]
Stable Identifier
R-BTA-975554
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
SKP2, A7MB09
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
G1/S Transition (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Association of Cks1 with SCF(Skp2) complex (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Ubiquitination of phospho-p27/p21 (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
APC/C:Cdh1 polyubiquitinates SKP2 (Bos taurus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Association of Cks1 with SCF(Skp2) complex (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Ubiquitination of phospho-p27/p21 (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
Regulation of BACH1 activity (Bos taurus)
BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
DNA Replication (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX2 (Bos taurus)
Regulation of RUNX2 expression and activity (Bos taurus)
SCF(SKP2) complex binds RUNX2 (Bos taurus)
RUNX2:SCF(SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)
RUNX2:SCF(SKP2) [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP13 binds UFD1L:SKP2 (Bos taurus)
UFD1L:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
USP13:UFD1L:SKP2 [nucleoplasm] (Bos taurus)
UFD1L:SKP2 [nucleoplasm] (Bos taurus)
SKP2 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:A7MB09
Gene Names
SKP2
Reference Genes
BioGPS Gene:519018 SKP2
ENSEMBL:ENSBTAG00000013562.6
KEGG:bta:519018 SKP2
Monarch:519018 SKP2
NCBI Gene:519018 SKP2
UCSC:A7MB09 SKP2
Reference Transcript
RefSeq:NM_001102052.1 SKP2
Participates
as a component of
UFD1L:SKP2 [nucleoplasm] (Bos taurus)
SCF (SKP2) complex [nucleoplasm] (Bos taurus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Bos taurus)
CUL1:SKP1:SKP2 [nucleoplasm] (Bos taurus)
as an input of
RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)
Other forms of this molecule
SKP2 [cytosol]
SKP2 [nucleoplasm]
Inferred From
SKP2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001095522.1
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