Reactome | RPS27L [cytosol]

RPS27L [cytosol]

Stable Identifier

R-BTA-8868849

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

RPS27L, Q3T0B7

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
- rRNA processing (Bos taurus)
  - rRNA processing in the nucleus and cytosol (Bos taurus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Bos taurus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Translation (Bos taurus)
  - Eukaryotic Translation Initiation (Bos taurus)
    - Cap-dependent Translation Initiation (Bos taurus)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Bos taurus)
        
        Translation initiation complex formation (Bos taurus)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        48S complex [cytosol] (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - Formation of a pool of free 40S subunits (Bos taurus)
        
        Release of 40S and 60S subunits from the 80S ribosome (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        eIF3 and eIF1A bind to the 40S subunit (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        40S:eIF3:eIF1A [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - Formation of the ternary complex, and subsequently, the 43S complex (Bos taurus)
        
        Formation of the 43S pre-initiation complex (Bos taurus)
        
        40S:eIF3:eIF1A [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Bos taurus)
        
        The 60S subunit joins the translation initiation complex (Bos taurus)
        
        40S:Met-tRNAi:mRNA [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        eIF5B:GTP is hydrolyzed and released (Bos taurus)
        
        80S:Met-tRNAi:mRNA [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - Ribosomal scanning and start codon recognition (Bos taurus)
        
        Ribosomal scanning (Bos taurus)
        
        48S complex [cytosol] (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        Start codon recognition (Bos taurus)
        
        48S complex [cytosol] (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Bos taurus)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Bos taurus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Bos taurus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Bos taurus)
        
        43S complex [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
  - Ribosome-associated quality control (Bos taurus)
    - PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Bos taurus)
      - ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Bos taurus)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Bos taurus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide (Bos taurus)
        
        ABCE1:ADP:40S ribosomal subunit [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide (Bos taurus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Bos taurus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
    - ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Bos taurus)
      - RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide (Bos taurus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        K63polyUb-80S ribosome [cytosol] (Bos taurus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] (Bos taurus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        K63polyUb-80S ribosome [cytosol] (Bos taurus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Bos taurus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        K63polyUb-80S ribosome [cytosol] (Bos taurus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Bos taurus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Bos taurus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Bos taurus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
  - SRP-dependent cotranslational protein targeting to membrane (Bos taurus)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)
      - SRP:polypeptide+signal:ribosome [cytosol] (Bos taurus)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS27,RPS27L [cytosol] (Bos taurus)
        
        RPS27L [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q3T0B7

Gene Names

RPS27L

Reference Genes

BioGPS Gene:614220 RPS27L

ENSEMBL:ENSBTAG00000012898

KEGG:bta:614220 RPS27L

Monarch:614220 RPS27L

NCBI Gene:614220 RPS27L

UCSC:Q3T0B7 RPS27L

Other Identifiers

101903478

101905167

614220

Bt.13898.1.S1_at

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0008270

GO:0016020

GO:0046872

GO:1990904

Participates

as a candidate of

RPS27,RPS27L [cytosol] (Bos taurus)

Other forms of this molecule

RPS27L [nucleoplasm]

Inferred From

RPS27L [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001035668.1

ENSEMBL

ENSBTAP00000084616, ENSBTAG00000075060, ENSBTAT00000139552, ENSBTAT00000108121, ENSBTAG00000012898, ENSBTAP00000105097

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