Reactome | KBTBD6 [cytosol]

KBTBD6 [cytosol]

Stable Identifier

R-BTA-8863221

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

KBTBD6, E1BF94

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KBTBD6 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BF94

Gene Names

KBTBD6

Reference Genes

ENSEMBL:ENSBTAG00000008656.5

UCSC:E1BF94 KBTBD6

Other Identifiers

538461

Bt.16187.1.A1_at

Bt.18286.1.A1_at

GO:0005515

GO:0005634

GO:0005737

GO:0030163

GO:0031463

GO:0035020

GO:0043161

GO:0070936

Participates

as a member of

BTB proteins [cytosol] (Bos taurus)

Inferred From

KBTBD6 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSBTAT00000011412, ENSBTAP00000011412, ENSBTAG00000008656

VGNC

53819

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