Reactome | FBXO41 [cytosol]

FBXO41 [cytosol]

Stable Identifier

R-BTA-8862623

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

FBXO41, E1BK68

Locations in the PathwayBrowser

Expand all

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        F-box protein [cytosol] (Bos taurus)
        
        FBXO41 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BK68

Gene Names

FBXO41

Reference Genes

BioGPS Gene:536077 FBXO41

ENSEMBL:ENSBTAG00000012759.4

KEGG Gene (Bos taurus):536077 FBXO41

Monarch:536077 FBXO41

NCBI Gene:536077 FBXO41

Reference Transcript

Other Identifiers

536077

GO:0005515

Participates

as a member of

F-box protein [cytosol] (Bos taurus)

Inferred From

FBXO41 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_001788408.2, XP_002691259.2

OpenTargets

ENSG00000163013

Ensembl

ENSBTAT00000016959, ENSBTAP00000016959, ENSBTAG00000012759

VGNC

28912

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