Reactome | phospho-IFNGR1 [plasma membrane]

phospho-IFNGR1 [plasma membrane]

Stable Identifier

R-BTA-873798

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

p-Y457-IFNGR1, F1MXR5

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Interferon Signaling (Bos taurus)
    - Interferon gamma signaling (Bos taurus)
      - Binding of STAT1 to p-IFNGR1 (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
      - IFNG signaling activates MAPKs (Bos taurus)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
        
        JAK1-mediated phosphorylation of RAF1 (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
      - Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
      - Phosphorylation of STAT1 at Ser727 (Bos taurus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
      - Phosphorylation of STAT1 by JAK kinases (Bos taurus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
      - Release of STAT1 dimer from active receptor unit (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Bos taurus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Bos taurus)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)
        
        phospho-IFNGR1 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MXR5

Gene Names

IFNGR1

Reference Genes

ENSEMBL:ENSBTAG00000012544.5

Other Identifiers

508619

GO:0002376

GO:0004896

GO:0005515

GO:0016020

GO:0019221

GO:0019955

GO:0023052

GO:0060089

GO:0060333

GO:0098542

Participates

as a component of

p-IFNGR1:p-JAK1 [plasma membrane] (Bos taurus)

Other forms of this molecule

IFNGR1 [plasma membrane]

Inferred From

p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 457 (in Homo sapiens)

Coordinate

457

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000027697

Ensembl

ENSBTAP00000016650, ENSBTAT00000016650, ENSBTAG00000012544

VGNC

30058

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