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SOCS3 [cytosol]
Stable Identifier
R-BTA-873794
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SOCS3, Q9BEG9
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Activation of JAK kinases (Bos taurus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Interferon gamma signaling (Bos taurus)
Regulation of IFNG signaling (Bos taurus)
SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Transphosphorylation of JAK1 (Bos taurus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Signaling by CSF3 (G-CSF) (Bos taurus)
Inactivation of CSF3 (G-CSF) signaling (Bos taurus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Bos taurus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
SOCS3 binds IL6ST (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Activates STAT3 (Bos taurus)
SOCS3 binds activated PTK6 (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
p-Y342-PTK6:SOCS3 [cytosol] (Bos taurus)
SOCS3 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q9BEG9
Gene Names
SOCS3
Reference Genes
BioGPS Gene:282081 SOCS3
ENSEMBL:ENSBTAG00000008441
ENSEMBL:ENSBTAG00000008441.3 SOCS3
KEGG Gene (Bos taurus):282081 SOCS3
Monarch:282081 SOCS3
NCBI Gene:282081 SOCS3
Reference Transcript
RefSeq:NM_174466.2 SOCS3
RefSeq:XM_005221139.3 SOCS3
Other Identifiers
282081
GO:0023052
GO:0035556
Participates
as a member of
CUL5-box protein [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
as an input of
SOCS3 binds IL6ST (Bos taurus)
SOCS3 binds activated PTK6 (Bos taurus)
as a component of
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Bos taurus)
p-Y342-PTK6:SOCS3 [cytosol] (Bos taurus)
Inferred From
SOCS3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005221196.1
,
NP_776891.1
OpenTargets
ENSG00000184557
Ensembl
ENSBTAG00000008441
,
ENSBTAP00000011106
,
ENSBTAT00000011106
VGNC
35121
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