Reactome | RPS8 [cytosol]

RPS8 [cytosol]

Stable Identifier

R-BTA-72385

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

RPS8, Q5E958

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)
- rRNA processing (Bos taurus)
  - rRNA processing in the nucleus and cytosol (Bos taurus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Bos taurus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS8 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q5E958

Gene Names

RPS8

Reference Genes

BioGPS Gene:404140 RPS8

ENSEMBL:ENSBTAG00000015285

KEGG:bta:404140 RPS8

Monarch:404140 RPS8

NCBI Gene:404140 RPS8

UCSC:Q5E958 RPS8

Reference Transcript

RefSeq:NM_001025317.1 RPS8

Participates

as a component of

Other forms of this molecule

RPS8 [nucleoplasm]

Inferred From

RPS8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001020488.1

VGNC

34151

PDB

7ZJW, 7ZJX, 6MTD, 6MTE

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