Reactome | RPS12 [cytosol]

RPS12 [cytosol]

Stable Identifier

R-BTA-72329

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

RPS12, Q76I81

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)
- rRNA processing (Bos taurus)
  - rRNA processing in the nucleus and cytosol (Bos taurus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Bos taurus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)
        
        40S ribosomal complex [cytosol] (Bos taurus)
        
        RPS12 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q76I81

Gene Names

RPS12

Reference Genes

BioGPS Gene:326582 RPS12

ENSEMBL:ENSBTAG00000001360

KEGG:bta:326582 RPS12

Monarch:326582 RPS12

NCBI Gene:326582 RPS12

UCSC:Q76I81 RPS12

Reference Transcript

Other Identifiers

326582

Bt.1269.1.S1_a_at

GO:0003735

GO:0005198

GO:0005794

GO:0005829

GO:0005840

GO:0006412

GO:0022626

GO:0022627

GO:0032040

GO:0042274

GO:0090263

Participates

as a component of

Other forms of this molecule

RPS12 [nucleoplasm]

Inferred From

RPS12 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001014409.1, XP_005210987.1, XP_005210988.1

ENSEMBL

ENSBTAG00000001360, ENSBTAT00000001791, ENSBTAP00000001791

VGNC

56365

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