Reactome | SRSF5 [nucleoplasm]

SRSF5 [nucleoplasm]

Stable Identifier

R-BTA-72028

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

SRSF5, A6H7B7

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
  - Formation of pre-mRNPs (Bos taurus)
    - Alternative Splicing Factors [nucleoplasm] (Bos taurus)
      - nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
      - Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
  - Transport of Mature Transcript to Cytoplasm (Bos taurus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Bos taurus)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Bos taurus)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
  - mRNA 3'-end processing (Bos taurus)
    - mRNA Polyadenylation (Bos taurus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Bos taurus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Bos taurus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Bos taurus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - Core CPA complex binds capped pre-mRNA (Bos taurus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - PP1 dephosphorylates RNA Pol II (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - RBBP6 activates CPSF complex (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
  - mRNA Splicing (Bos taurus)
    - mRNA Splicing - Major Pathway (Bos taurus)
      - Formation of the Spliceosomal Bact complex (Bos taurus)
        
        Spliceosomal B complex [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Spliceosomal Bact complex [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal C complex containing intron lariat (Bos taurus)
        
        Spliceosomal B* complex [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Spliceosomal C complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal C* complex (Bos taurus)
        
        Spliceosomal C complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Spliceosomal C* complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal E complex (Bos taurus)
        
        Spliceosomal E complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal P complex and exon ligation (Bos taurus)
        
        Spliceosomal C* complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        Spliceosomal P complex [nucleoplasm] (Bos taurus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Bos taurus)
        
        Spliceosomal P complex [nucleoplasm] (Bos taurus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        nonshuttling SRSFs [nucleoplasm] (Bos taurus)
        
        SRSF5 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A6H7B7

Gene Names

SRSF5

Reference Genes

BioGPS Gene:510474 SRSF5

ENSEMBL:ENSBTAG00000011596.5

KEGG:bta:510474 SRSF5

Monarch:510474 SRSF5

NCBI Gene:510474 SRSF5

UCSC:A6H7B7 SRSF5

Reference Transcript

Participates

as a member of

nonshuttling SRSFs [nucleoplasm] (Bos taurus)

as a component of

Inferred From

SRSF5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001092399.1, XP_005212013.1, XP_005212015.1, XP_005212014.1

VGNC

52831

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