Reactome | PTBP1 [nucleoplasm]

PTBP1 [nucleoplasm]

Stable Identifier

R-BTA-71923

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

PTBP1, Q8WN55

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Processing of Capped Intron-Containing Pre-mRNA (Bos taurus)
  - Formation of pre-mRNPs (Bos taurus)
    - Alternative Splicing Factors [nucleoplasm] (Bos taurus)
      - PTBP1 [nucleoplasm] (Bos taurus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
      - Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
  - mRNA 3'-end processing (Bos taurus)
    - mRNA Polyadenylation (Bos taurus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Bos taurus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Bos taurus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Bos taurus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - Core CPA complex binds capped pre-mRNA (Bos taurus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Bos taurus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - PP1 dephosphorylates RNA Pol II (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - RBBP6 activates CPSF complex (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Bos taurus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Bos taurus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
  - mRNA Splicing (Bos taurus)
    - mRNA Splicing - Major Pathway (Bos taurus)
      - Formation of the Spliceosomal Bact complex (Bos taurus)
        
        Spliceosomal B complex [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Spliceosomal Bact complex [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal C complex containing intron lariat (Bos taurus)
        
        Spliceosomal B* complex [nucleoplasm] (Bos taurus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Spliceosomal C complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal C* complex (Bos taurus)
        
        Spliceosomal C complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Spliceosomal C* complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal E complex (Bos taurus)
        
        Spliceosomal E complex [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - Formation of the Spliceosomal P complex and exon ligation (Bos taurus)
        
        Spliceosomal C* complex [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        Spliceosomal P complex [nucleoplasm] (Bos taurus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Bos taurus)
        
        Spliceosomal P complex [nucleoplasm] (Bos taurus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Bos taurus)
        
        Alternative Splicing Factors [nucleoplasm] (Bos taurus)
        
        PTBP1 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q8WN55

Gene Names

PTBP1

Reference Genes

BioGPS Gene:282018 PTBP1

ENSEMBL:ENSBTAG00000045828

KEGG:bta:282018 PTBP1

Monarch:282018 PTBP1

NCBI Gene:282018 PTBP1

UCSC:Q8WN55 PTBP1

Reference Transcript

Other Identifiers

282018

Bt.9031.1.S1_at

GO:0000381

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0006355

GO:0006397

GO:0008380

GO:0010467

GO:0010629

GO:0016071

GO:0022008

GO:0030154

GO:0033119

GO:0036002

GO:0043484

GO:0045595

GO:0045665

GO:0045944

GO:0048025

GO:0051148

GO:0070886

GO:0075522

GO:1903312

Participates

as a member of

Alternative Splicing Factors [nucleoplasm] (Bos taurus)

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Bos taurus)

as a component of

FGFR2 IIIc-specific splicing complex [nucleoplasm] (Bos taurus)

Inferred From

PTBP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001289713.1, NP_776867.1

ENSEMBL

ENSBTAP00000054889, ENSBTAP00000066720, ENSBTAG00000045828, ENSBTAT00000071097, ENSBTAT00000066209

VGNC

52809

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