Reactome | ZNF830 [nucleoplasm]

ZNF830 [nucleoplasm]

Stable Identifier

R-BTA-6781962

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

ZNF830, A3KN01

Locations in the PathwayBrowser

Expand all

DNA Repair (Bos taurus)

- Nucleotide Excision Repair (Bos taurus)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
    - Dual incision in TC-NER (Bos taurus)
      - 3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)
        
        TC-NER incision complex [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)
        
        TC-NER incision complex [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
        
        TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - ERCC5 and RPA bind TC-NER site (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
    - Formation of TC-NER Pre-Incision Complex (Bos taurus)
      - Assembly of the pre-incision complex in TC-NER (Bos taurus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
        
        TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Bos taurus)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        XAB2 complex [nucleoplasm] (Bos taurus)
        
        ZNF830 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A3KN01

Gene Names

ZNF830

Reference Genes

BioGPS Gene:539497 ZNF830

ENSEMBL:ENSBTAG00000020340.3

KEGG:bta:539497 ZNF830

Monarch:539497 ZNF830

NCBI Gene:539497 ZNF830

UCSC:A3KN01 ZNF830

Reference Transcript

RefSeq:NM_001082612.2 ZNF830

Other Identifiers

539497

Bt.27276.1.A1_at

GO:0000278

GO:0001541

GO:0001546

GO:0001832

GO:0003676

GO:0005634

GO:0005681

GO:0006396

GO:0008270

GO:0016607

GO:0022414

GO:0022600

GO:0033260

GO:0033314

GO:0043066

GO:0044773

GO:0048856

GO:0051276

GO:0060729

Participates

as a component of

Inferred From

ZNF830 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001076081.1

ENSEMBL

ENSBTAT00000101380, ENSBTAG00000020340, ENSBTAP00000083931

VGNC

37354

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