Reactome | MonoUb:K164-PCNA homotrimer [nucleoplasm]

MonoUb:K164-PCNA homotrimer [nucleoplasm]

Stable Identifier

R-BTA-5651993

Type

Complex

Species

Bos taurus

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Bos taurus)

- DNA Damage Bypass (Bos taurus)
  - Recognition of DNA damage by PCNA-containing replication complex (Bos taurus)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Bos taurus)
      - MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - USP1:WDR48 binds monoUb:K164-PCNA (Bos taurus)
      - MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)
      - MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Bos taurus)
    - Termination of translesion DNA synthesis (Bos taurus)
      - TRIM25 binds monoUb:164-PCNA (Bos taurus)
        
        DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Bos taurus)
        
        DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Bos taurus)
        
        UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Bos taurus)
        
        DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - Translesion Synthesis by POLH (Bos taurus)
      - Elongation by POLH (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - Insertion of correct bases opposite the lesion by POLH (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Bos taurus)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - Translesion synthesis by POLI (Bos taurus)
      - POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - POLZ elongates POLI-incorporated dNMP (Bos taurus)
        
        POLI:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - Translesion synthesis by POLK (Bos taurus)
      - POLK and POLZ cooperate in elongation of mispaired primer termini (Bos taurus)
        
        POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - Translesion synthesis by REV1 (Bos taurus)
      - POLZ extends translesion synthesis (Bos taurus)
        
        POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Bos taurus)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - REV1 binds AP-dsDNA (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - REV1 inserts dCMP opposite to AP sites in DNA (Bos taurus)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - REV1 recruits POLZ to (AP:Cyt)-DNA Template (Bos taurus)
        
        POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Bos taurus)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
- DNA Double-Strand Break Repair (Bos taurus)
  - Homology Directed Repair (Bos taurus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Bos taurus)
      - HDR through Homologous Recombination (HRR) (Bos taurus)
        
        D-loop extension by DNA polymerases (Bos taurus)
        
        PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC:POLH,POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
- Nucleotide Excision Repair (Bos taurus)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
    - Dual Incision in GG-NER (Bos taurus)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        PCNA homotrimer,MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Bos taurus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
    - Dual incision in TC-NER (Bos taurus)
      - 3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)
        
        PCNA homotrimer,MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Bos taurus)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Bos taurus)
        
        MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an input of

as a component of

as a member of

PCNA homotrimer,MonoUb:K164-PCNA homotrimer [nucleoplasm] (Bos taurus)

Inferred From

MonoUb:K164-PCNA homotrimer [nucleoplasm] (Homo sapiens)

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