Reactome | phospho-RIPK1 [cytosol]

phospho-RIPK1 [cytosol]

Stable Identifier

R-BTA-5218872

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

p-S166-RIPK1, Q3SZK6

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Bos taurus)

- Regulated Necrosis (Bos taurus)
  - RIPK1-mediated regulated necrosis (Bos taurus)
    - MLKL binds PIPs (Bos taurus)
      - RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
    - RIPK1 is phosphorylated (Bos taurus)
      - p-S-RIPK1:RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
    - RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)
      - (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
    - RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Bos taurus)
      - p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
    - RIPK3 is phosphorylated (Bos taurus)
      - p-S-RIPK1:RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
    - RIPK3 phosphorylates MLKL (Bos taurus)
      - (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
    - Regulation of necroptotic cell death (Bos taurus)
      - ATP binds MLKL (Bos taurus)
        
        (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - ITCH polyubiquitinates MLKL at K50 (Bos taurus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xK63PolyUb-K50,p-T357,S358-MLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - MLKL binds FLOT1, FLOT2 (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - MLKL binds IP4, IP5 and IP6 (Bos taurus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Bos taurus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - MLKL binds ITCH (Bos taurus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
        
        (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - MLKL binds PDCD6IP and SDCBP (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - PELI1 binds activated RIPK1:RIPK3 (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:PELI1 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
      - PELI1 ubiquitinates RIPK3 at K363 (Bos taurus)
        
        p-S-RIPK1:p-S199,227, K48pUb-363-RIPK3:PELI1 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)
        
        p-S-RIPK1:p-S199,227-RIPK3:PELI1 [cytosol] (Bos taurus)
        
        phospho-RIPK1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q3SZK6

Gene Names

RIPK1

Reference Genes

BioGPS Gene:504727 RIPK1

ENSEMBL:ENSBTAG00000006378.4

KEGG:bta:504727 RIPK1

Monarch:504727 RIPK1

NCBI Gene:504727 RIPK1

UCSC:Q3SZK6 RIPK1

Reference Transcript

Participates

as a component of

Other forms of this molecule

RIPK1 [cytosol]

phospho-RIPK1 [cytosol]

RIPK1 [cytosol]

phospho-RIPK1 [cytosol]

RIPK1 [cytosol]

Inferred From

p-S166-RIPK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 166 (in Homo sapiens)

Coordinate

166

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001030184.1, XP_005223901.1, XP_005223900.1

VGNC

33981

Cite Us!