Reactome | FZD4 [clathrin-coated endocytic vesicle membrane]

FZD4 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-BTA-5138457

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

FZD4, F1MLJ8

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Signaling by WNT (Bos taurus)
  - Beta-catenin independent WNT signaling (Bos taurus)
    - PCP/CE pathway (Bos taurus)
      - WNT5A-dependent internalization of FZD4 (Bos taurus)
        
        WNT5A:FZD4 is endocytosed (Bos taurus)
        
        WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        FZD4 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MLJ8

Gene Names

FZD4

Reference Genes

BioGPS Gene:445416 FZD4

ENSEMBL:ENSBTAG00000040128.4

KEGG Gene (Bos taurus):445416 FZD4

Monarch:445416 FZD4

NCBI Gene:445416 FZD4

Reference Transcript

RefSeq:NM_001206269.1 FZD4

Participates

as a component of

Other forms of this molecule

FZD4 [plasma membrane]

Inferred From

FZD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_001193198.1

OpenTargets

ENSG00000174804

VGNC

29168

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