Reactome | APEX1 [nucleoplasm]

APEX1 [nucleoplasm]

Stable Identifier

R-BTA-50119

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

A0A140T846

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:A0A140T846

Reference Genes

BioGPS Gene:281630

ENSEMBL:ENSBTAG00000002745.5

KEGG Gene (Bos taurus):281630

Monarch:281630

NCBI Gene:281630

Reference Transcript

RefSeq:NM_176609.3

Other Identifiers

281630

GO:0003677

GO:0003824

GO:0003906

GO:0004518

GO:0004519

GO:0005634

GO:0005737

GO:0005739

GO:0006281

GO:0006284

GO:0006310

GO:0006974

GO:0008081

GO:0008311

GO:0016787

GO:0043226

GO:0046872

GO:0140097

Participates

as an output of

Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Bos taurus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Bos taurus)

as a component of

LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Bos taurus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Bos taurus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Bos taurus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Bos taurus)
APEX1:AP-dsDNA [nucleoplasm] (Bos taurus)

as an input of

Displacement of TDG glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of MPG glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Bos taurus)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Bos taurus)

Inferred From

APEX1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_788782.2

Ensembl

ENSBTAP00000003559, ENSBTAG00000002745, ENSBTAT00000003559

VGNC

26011

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