Reactome | HERC2 [nucleoplasm]

HERC2 [nucleoplasm]

Stable Identifier

R-BTA-4551680

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

HERC2, E1B782

Locations in the PathwayBrowser

Expand all

DNA Repair (Bos taurus)

- DNA Double-Strand Break Repair (Bos taurus)
  - DNA Double Strand Break Response (Bos taurus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
      - ATM phosphorylates HERC2 (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Bos taurus)
        
        HERC2 [nucleoplasm] (Bos taurus)
      - HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Bos taurus)
        
        HERC2 [nucleoplasm] (Bos taurus)
        
        HERC2 [nucleoplasm] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - SUMOylation (Bos taurus)
    - SUMO E3 ligases SUMOylate target proteins (Bos taurus)
      - SUMOylation of DNA damage response and repair proteins (Bos taurus)
        
        PIAS4 SUMOylates HERC2 with SUMO1 (Bos taurus)
        
        HERC2 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:E1B782

Gene Names

HERC2

Reference Genes

BioGPS Gene:535440 HERC2

ENSEMBL:ENSBTAG00000013916.6

KEGG:bta:535440 HERC2

Monarch:535440 HERC2

NCBI Gene:535440 HERC2

UCSC:E1B782 HERC2

Reference Transcript

Other Identifiers

535440

Bt.22003.1.S1_at

GO:0003824

GO:0004842

GO:0007283

GO:0008270

GO:0016567

GO:0016740

GO:0022414

GO:0030163

GO:0030182

GO:0043161

GO:0045746

GO:0046872

GO:0140096

Participates

as an input of

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Bos taurus)

Other forms of this molecule

HERC2 [nucleoplasm]

HERC2 [cytosol]

phospho-HERC2 [nucleoplasm]

Inferred From

HERC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001193010.1, XP_010800081.1, XP_015329797.1

ENSEMBL

ENSBTAG00000013916, ENSBTAP00000018496, ENSBTAT00000018496

VGNC

59172

Cite Us!