Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IL6ST [plasma membrane]
Stable Identifier
R-BTA-448453
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
IL6ST, E1BD36
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-12 family signaling (Bos taurus)
Interleukin-27 signaling (Bos taurus)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Bos taurus)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
Interleukin-27 binds Interleukin-27 receptor (Bos taurus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Bos taurus)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
Interleukin-35 Signalling (Bos taurus)
IL35 binds IL-12RB2:IL6ST receptor (Bos taurus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL35 binds IL6ST:IL6ST receptor (Bos taurus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Bos taurus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Bos taurus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Bos taurus)
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Bos taurus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
STAT1 associates with IL6ST:IL6ST (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Bos taurus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
p-STAT1 dissociates from IL6ST:IL6ST (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
Interleukin-6 family signaling (Bos taurus)
IL-6-type cytokine receptor ligand interactions (Bos taurus)
LIFR:JAKs bind gp130:JAKs:CNTFR (Bos taurus)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:gp130:JAKs:LIFR:JAKs [plasma membrane] (Bos taurus)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
LIF,OSM receptor complex:gp130 [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
gp130:JAKs bind CNTFR (Bos taurus)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
Interleukin-6 signaling (Bos taurus)
Assembly of hexameric IL-6 receptor (Bos taurus)
IL6 receptor hexamer:JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6ST is tyrosine phosphorylated (Bos taurus)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
JAK activation (Bos taurus)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6 receptor hexamer:JAKs [plasma membrane] (Bos taurus)
IL6 receptor trimer:JAKs [plasma membrane] (Bos taurus)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6ST [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BD36
Gene Names
IL6ST
Reference Genes
BioGPS Gene:522155 IL6ST
ENSEMBL:ENSBTAG00000017745.4
ENSEMBL:ENSBTAG00000017745.5 IL6ST
KEGG Gene (Bos taurus):522155 IL6ST
Monarch:522155 IL6ST
NCBI Gene:522155 IL6ST
Reference Transcript
RefSeq:XM_010824731.2 IL6ST
RefSeq:XM_600430.9 IL6ST
RefSeq:XM_002696322.5 IL6ST
RefSeq:XM_010816769.2 IL6ST
Other Identifiers
522155
GO:0002376
GO:0004896
GO:0004897
GO:0004915
GO:0004921
GO:0004923
GO:0004924
GO:0005127
GO:0005138
GO:0005886
GO:0005896
GO:0005900
GO:0005975
GO:0005977
GO:0006091
GO:0007155
GO:0007165
GO:0008284
GO:0008593
GO:0009897
GO:0012501
GO:0015026
GO:0016020
GO:0019221
GO:0019838
GO:0019955
GO:0019970
GO:0019981
GO:0023052
GO:0030154
GO:0030296
GO:0030425
GO:0034097
GO:0036211
GO:0038154
GO:0038165
GO:0042102
GO:0042531
GO:0042802
GO:0043025
GO:0043235
GO:0043524
GO:0044297
GO:0045121
GO:0045669
GO:0045747
GO:0048711
GO:0048856
GO:0048861
GO:0060089
GO:0060576
GO:0070102
GO:0070106
GO:0070110
GO:0070120
GO:0097110
GO:0098772
Participates
as a component of
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Bos taurus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Bos taurus)
IL6ST:p-JAK1 [plasma membrane] (Bos taurus)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Bos taurus)
LIF,OSM receptor complex:gp130 [plasma membrane] (Bos taurus)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Bos taurus)
IL6RB:Activated JAKs [plasma membrane] (Bos taurus)
as an input of
OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)
Other forms of this molecule
phospho-IL6ST [plasma membrane]
IL6ST [extracellular region]
phospho-IL6ST [plasma membrane]
Inferred From
IL6ST [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_600430.6
,
XP_010823033.1
,
XP_010815071.1
,
XP_002696368.3
OpenTargets
ENSG00000134352
Ensembl
ENSBTAG00000017745
,
ENSBTAT00000023595
,
ENSBTAP00000023595
VGNC
30168
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text