Reactome | CHRM2 [plasma membrane]

CHRM2 [plasma membrane]

Stable Identifier

R-BTA-390654

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

CHRM2, P41985

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - ARRB bind GPCRs (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        ARRB-binding GPCRs [plasma membrane] (Bos taurus)
        
        CHRM2 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:P41985

Gene Names

CHRM2

Reference Genes

BioGPS Gene:522170 CHRM2

ENSEMBL:ENSBTAG00000014674

KEGG:bta:522170 CHRM2

Monarch:522170 CHRM2

NCBI Gene:522170 CHRM2

UCSC:P41985 CHRM2

Reference Transcript

Other Identifiers

522170

Bt.26467.1.A1_at

GO:0004930

GO:0005730

GO:0005794

GO:0005815

GO:0005886

GO:0005929

GO:0007186

GO:0007197

GO:0007213

GO:0008016

GO:0009615

GO:0016020

GO:0016907

GO:0036064

GO:0043226

GO:0098981

GO:0099171

GO:1990763

Participates

as a member of

ARRB-binding GPCRs [plasma membrane] (Bos taurus)

as an input of

as a component of

Other forms of this molecule

CHRM2 [clathrin-coated endocytic vesicle membrane]

Inferred From

CHRM2,CHRM4 [plasma membrane] (Homo sapiens)

CHRM2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005205909.1, NP_001074202.1

ENSEMBL

ENSBTAP00000086722, ENSBTAT00000019534, ENSBTAG00000014674, ENSBTAT00000135328, ENSBTAP00000019534

VGNC

27319

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