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NCOA2 [nucleoplasm]
Stable Identifier
R-BTA-376398
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
NCOA2, E1BPY4
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
Fatty acid ligands activate PPARA (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
PPARA:RXRA Coactivator complex [nucleoplasm] (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
Cytochrome P450 - arranged by substrate type (Bos taurus)
Endogenous sterols (Bos taurus)
CYP7A1 7-hydroxylates CHOL (Bos taurus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Bos taurus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Synthesis of bile acids and bile salts (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
CYP7A1 7-hydroxylates CHOL (Bos taurus)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Regulation of lipid metabolism by PPARalpha (Bos taurus)
Fatty acid ligands activate PPARA (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
PPARA:RXRA Coactivator complex [nucleoplasm] (Bos taurus)
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Estrogen-dependent gene expression (Bos taurus)
HATs and coactivators are recruited to the CTSD gene (Bos taurus)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Bos taurus)
NCOAs [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
NCOAs [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases activate PKNs (Bos taurus)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Bos taurus)
PKN1 stimulates association of AR with NCOA2 (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
p-T774-PKN1:AR:Androgen:NCOA2 [nucleoplasm] (Bos taurus)
NCOA2 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BPY4
Gene Names
NCOA2
Reference Genes
ENSEMBL:ENSBTAG00000020312.5
ENSEMBL:ENSBTAG00000020312.6 NCOA2
Reference Transcript
RefSeq:XM_010812087.2 NCOA2
RefSeq:XM_015466332.1 NCOA2
RefSeq:XM_015474472.1 NCOA2
RefSeq:XM_010825333.2 NCOA2
RefSeq:XM_015466326.1 NCOA2
RefSeq:XM_015466330.1 NCOA2
RefSeq:XM_015466333.1 NCOA2
RefSeq:XM_015466328.1 NCOA2
RefSeq:XM_015474473.1 NCOA2
RefSeq:XM_015466327.1 NCOA2
RefSeq:XM_015466331.1 NCOA2
RefSeq:XM_015466329.1 NCOA2
RefSeq:XM_015474471.1 NCOA2
RefSeq:XM_002692724.5 NCOA2
Other Identifiers
508162
GO:0000122
GO:0000978
GO:0001162
GO:0003677
GO:0003682
GO:0003713
GO:0005102
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005975
GO:0006351
GO:0006355
GO:0006629
GO:0007623
GO:0010468
GO:0010906
GO:0016604
GO:0016922
GO:0017162
GO:0019216
GO:0019904
GO:0030374
GO:0032570
GO:0032922
GO:0032991
GO:0043226
GO:0045475
GO:0045892
GO:0045944
GO:0061629
GO:0140110
GO:1904017
Participates
as a candidate of
NCOAs [nucleoplasm] (Bos taurus)
as an input of
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Bos taurus)
PKN1 stimulates association of AR with NCOA2 (Bos taurus)
as a component of
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Bos taurus)
p-T774-PKN1:AR:Androgen:NCOA2 [nucleoplasm] (Bos taurus)
as a member of
Coactivators of PPARalpha [nucleoplasm] (Bos taurus)
Other forms of this molecule
NCOA2 [nucleoplasm]
Inferred From
NCOA2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_015321819.1
,
XP_015321812.1
,
XP_015321814.1
,
XP_015321813.1
,
XP_015321816.1
,
XP_015321815.1
,
XP_002692770.3
,
XP_015321817.1
,
XP_015329959.1
,
XP_010823635.1
,
XP_010810389.1
,
XP_015329957.1
,
XP_015321818.1
,
XP_015329958.1
OpenTargets
ENSG00000140396
Ensembl
ENSBTAG00000020312
,
ENSBTAT00000080172
,
ENSBTAP00000067457
,
ENSBTAP00000027071
,
ENSBTAT00000027071
VGNC
50226
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