Reactome | CLASP2 [cytosol]

CLASP2

Stable Identifier

R-BTA-376252

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

E1BQ15

Locations in the PathwayBrowser

Expand all

Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - Mitotic Spindle Checkpoint (Bos taurus)
    - Amplification of signal from the kinetochores (Bos taurus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Bos taurus)
        
        MAD2 associates with the Mad1 kinetochore complex (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Mad1 binds kinetochore (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Release of activated MAD2 from kinetochores (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
- Cell Cycle, Mitotic (Bos taurus)
  - M Phase (Bos taurus)
    - Mitotic Metaphase and Anaphase (Bos taurus)
      - Mitotic Anaphase (Bos taurus)
        
        Separation of Sister Chromatids (Bos taurus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Separation of sister chromatids (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
    - Mitotic Prometaphase (Bos taurus)
      - Kinetochore capture of astral microtubules (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
      - Resolution of Sister Chromatid Cohesion (Bos taurus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Kinetochore assembly (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        CLASP2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BQ15

Reference Genes

ENSEMBL:ENSBTAG00000011333

Other Identifiers

531418

CLASP2

DAAA02053586

DAAA02053587

DAAA02053588

ENSBTAG00000011333

ENSBTAP00000015071

ENSBTAT00000015071

EntrezGene:531418

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0005829

GO:0043226

IPR000357

IPR016024

IPR021133

IPR024395

NM_001191201

NP_001178130

PF02985

PF12348

UPI0002264AF2

XM_005222478

XM_005222479

XP_005222535

Participant Of

hasComponent

Kinetochore [cytosol]

Inferred From

CLASP2 [cytosol] (Homo sapiens)