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p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
Stable Identifier
R-BTA-2424468
Type
Complex
Species
Bos taurus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Release of p-PLCG1 (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Phosphorylation and activation of VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Phosphorylation of SLP-76 by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Recruitment of VAV to p-SLP-76 (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
p-SHC1:GRB2:SOS [cytosol]
(Bos taurus)
phospho-LAT [plasma membrane]
(Bos taurus)
Participates
as a component of
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
as an input of
Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)
as an output of
Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)
as a member of
RAS GEFs [plasma membrane] (Bos taurus)
Inferred From
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
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