Reactome | COL8A2 [extracellular region]

COL8A2 [extracellular region]

Stable Identifier

R-BTA-2192745

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL8A2, F1MJR6

Locations in the PathwayBrowser

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Extracellular matrix organization (Bos taurus)

- Collagen formation (Bos taurus)
  - Assembly of collagen fibrils and other multimeric structures (Bos taurus)
    - Formation of collagen networks (Bos taurus)
      - Collagen networks [extracellular region] (Bos taurus)
        
        Collagen type VIII fibril [extracellular region] (Bos taurus)
        
        Tropocollagen type VIII [extracellular region] (Bos taurus)
        
        COL8A2 [extracellular region] (Bos taurus)
      - Network forming tropocollagens [extracellular region] (Bos taurus)
        
        Tropocollagen type VIII [extracellular region] (Bos taurus)
        
        COL8A2 [extracellular region] (Bos taurus)
  - Collagen biosynthesis and modifying enzymes (Bos taurus)
    - Secretion of collagens (Bos taurus)
      - Collagens and tropocollagens [extracellular region] (Bos taurus)
        
        Non-fibrillar collagens [extracellular region] (Bos taurus)
        
        Tropocollagen type VIII [extracellular region] (Bos taurus)
        
        COL8A2 [extracellular region] (Bos taurus)
- Degradation of the extracellular matrix (Bos taurus)
  - Collagen degradation (Bos taurus)
    - Collagen type VIII degradation by MMP1 (Bos taurus)
      - Collagen type VIII fibril [extracellular region] (Bos taurus)
        
        Tropocollagen type VIII [extracellular region] (Bos taurus)
        
        COL8A2 [extracellular region] (Bos taurus)
- Integrin cell surface interactions (Bos taurus)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Bos taurus)
      - Collagen type VIII fibril [extracellular region] (Bos taurus)
        
        Tropocollagen type VIII [extracellular region] (Bos taurus)
        
        COL8A2 [extracellular region] (Bos taurus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Bos taurus)
        
        Collagen type VIII fibril [extracellular region] (Bos taurus)
        
        Tropocollagen type VIII [extracellular region] (Bos taurus)
        
        COL8A2 [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MJR6

Gene Names

COL8A2

Reference Genes

ENSEMBL:ENSBTAG00000010175.6

UCSC:F1MJR6 COL8A2

Other Identifiers

539415

Bt.2508.1.S1_at

GO:0001935

GO:0005515

GO:0048593

Participates

as a component of

Tropocollagen type VIII [extracellular region] (Bos taurus)

Other forms of this molecule

COL8A2 [endoplasmic reticulum lumen]

COL8A2 [extracellular region]

COL8A2 [endoplasmic reticulum lumen]

Inferred From

Collagen alpha-2(VIII) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL8A2 [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

ENSEMBL

ENSBTAT00000013427, ENSBTAG00000010175, ENSBTAP00000013427

VGNC

27575