Reactome | COL6A3 [extracellular region]

COL6A3 [extracellular region]

Stable Identifier

R-BTA-2192709

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL6A3(26-3177), E1BB91

Locations in the PathwayBrowser

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Extracellular matrix organization (Bos taurus)

- Collagen formation (Bos taurus)
  - Assembly of collagen fibrils and other multimeric structures (Bos taurus)
    - Formation of collagen networks (Bos taurus)
      - Collagen networks [extracellular region] (Bos taurus)
        
        Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
      - Network forming tropocollagens [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
  - Collagen biosynthesis and modifying enzymes (Bos taurus)
    - Secretion of collagens (Bos taurus)
      - Collagens and tropocollagens [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
- Degradation of the extracellular matrix (Bos taurus)
  - Collagen degradation (Bos taurus)
    - Collagen type VI degradation by MMP2,9,11 (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
- ECM proteoglycans (Bos taurus)
  - BGN binds Collagen types I, VI, (IX) (Bos taurus)
    - BGN:Collagen types I, VI, (IX) [extracellular region] (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
    - Collagen type VI fibril [extracellular region] (Bos taurus)
      - Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
  - DCN binds collagen I, II, III, VI fibrils (Bos taurus)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Bos taurus)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Bos taurus)
        
        Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
- Integrin cell surface interactions (Bos taurus)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Bos taurus)
        
        Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
  - Collagen types VI, IX bind integrin alpha10beta1 (Bos taurus)
    - Collagen tupe VI network, Collagen type IX:Integrin alpha10beta1 [plasma membrane] (Bos taurus)
      - Collagen type VI fibril [extracellular region] (Bos taurus)
        
        Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
    - Collagen type VI fibril [extracellular region] (Bos taurus)
      - Collagen type VI tetramer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI dimer [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by PDGF (Bos taurus)
    - PDGF binds to extracellular matrix proteins (Bos taurus)
      - Extracellular matrix ligands [extracellular region] (Bos taurus)
        
        Collagens [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)
      - PDGF A and B chains:ECM complex [extracellular region] (Bos taurus)
        
        Extracellular matrix ligands [extracellular region] (Bos taurus)
        
        Collagens [extracellular region] (Bos taurus)
        
        Tropocollagen type VI [extracellular region] (Bos taurus)
        
        Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)
        
        COL6A3 [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BB91

Gene Names

COL6A3

Reference Genes

ENSEMBL:ENSBTAG00000030190.4

UCSC:E1BB91 COL6A3

Other Identifiers

530657

Bt.12498.1.A1_at

GO:0004867

GO:0005515

GO:0005581

GO:0005615

GO:0009411

GO:0030312

GO:0031012

GO:0042383

GO:0043491

GO:0051402

GO:0098772

Participates

as a member of

Collagen alpha 3-6(VI) [extracellular region] (Bos taurus)

Other forms of this molecule

COL6A3 [endoplasmic reticulum lumen]

COL6A3 [extracellular region]

COL6A3 [endoplasmic reticulum lumen]

Inferred From

Collagen alpha-3(VI) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL6A3(26-3177) [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

ENSEMBL

ENSBTAP00000018479, ENSBTAG00000030190, ENSBTAT00000018479

VGNC

27572

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