Reactome | phospho-CD3G [plasma membrane]

phospho-CD3G [plasma membrane]

Stable Identifier

R-BTA-202362

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

p-Y160,Y171-CD3G, G8JL01

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Regulation of T cell activation by CD28 family (Bos taurus)
    - Co-inhibition by PD-1 (Bos taurus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
  - TCR signaling (Bos taurus)
    - Generation of second messenger molecules (Bos taurus)
      - Phosphorylation of PLC-gamma1 (Bos taurus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Phosphorylation of SLP-76 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Phosphorylation of TBSMs in LAT (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
    - Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
    - Translocation of ZAP-70 to Immunological synapse (Bos taurus)
      - Activation of ZAP-70 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - PTPN22 dephosphorylates ZAP70 (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Phosphorylation of ZAP-70 by Lck (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Bos taurus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
    - Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
      - Phosphorylation of VAV (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Recruitment of VAV1 to p-6Y-SYK (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
    - Role of phospholipids in phagocytosis (Bos taurus)
      - PI3K binds to p-6Y-SYK (Bos taurus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Phosphorylation and activation of PLCG (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Recruitment of PLCgamma to membrane (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
      - Release of PLCG from FCGR (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Bos taurus)
        
        p-FCGRs [plasma membrane] (Bos taurus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        p-Y160,Y171-CD3G dimer [plasma membrane] (Bos taurus)
        
        phospho-CD3G [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:G8JL01

Gene Names

CD3G

Reference Genes

BioGPS Gene:281055 CD3G

ENSEMBL:ENSBTAG00000006453.6

KEGG:bta:281055 CD3G

Monarch:281055 CD3G

NCBI Gene:281055 CD3G

UCSC:G8JL01 CD3G

Reference Transcript

RefSeq:NM_001040472.2 CD3G

Other Identifiers

281055

GO:0004888

GO:0005829

GO:0005886

GO:0007163

GO:0007166

GO:0015031

GO:0016020

GO:0042105

GO:0042802

GO:0070228

Participates

as a component of

Other forms of this molecule

CD3G [clathrin-coated endocytic vesicle membrane]

CD3G [plasma membrane]

Inferred From

p-Y160,Y171-CD3G [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 160 (in Homo sapiens)

Coordinate

160

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 171 (in Homo sapiens)

Coordinate

171

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001035562.2

ENSEMBL

ENSBTAT00000046953, ENSBTAP00000044200, ENSBTAG00000071227

VGNC

27031

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