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phospho-LCP2 [cytosol]
Stable Identifier
R-BTA-202175
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
p-Y113,128,145-LCP2, Q08DS6
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
SLP-76 stimulates PLC gamma 2 (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Syk activation leads to SLP-76 activation (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-SLP-76 binds VAV (Bos taurus)
p-SLP-76:VAV [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
TCR signaling (Bos taurus)
Generation of second messenger molecules (Bos taurus)
Disassociation of PLC-gamma1 from SLP-76 (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
NCK binds PAK (Bos taurus)
p-SLP-76:NCK1 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-SLP-76:NCK:PAK [cytosol] (Bos taurus)
p-SLP-76:NCK1 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Phosphorylation of PLC-gamma1 (Bos taurus)
PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Bos taurus)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Bos taurus)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Bos taurus)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Phosphorylation of SLP-76 (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Recruitment of ITK to SLP-76 (Bos taurus)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-SLP-76 binds ADAP (Bos taurus)
p-SLP-76:ADAP [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-SLP-76 binds NCK (Bos taurus)
p-SLP-76:NCK1 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
Activation of RAC1 by VAV2/3 (Bos taurus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Release of p-PLCG1 (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Activation of RAC1 by VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Phosphorylation and activation of VAV (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Phosphorylation of SLP-76 by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
Recruitment of VAV to p-SLP-76 (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q08DS6
Gene Names
LCP2
Reference Genes
BioGPS Gene:513244 LCP2
ENSEMBL:ENSBTAG00000009381.6
KEGG Gene (Bos taurus):513244 LCP2
Monarch:513244 LCP2
NCBI Gene:513244 LCP2
Reference Transcript
RefSeq:NM_001076844.2 LCP2
Other Identifiers
513244
GO:0007169
GO:0023052
GO:0035556
Participates
as an input of
p-SLP-76 binds VAV (Bos taurus)
p-SLP-76 binds ADAP (Bos taurus)
p-SLP-76 binds NCK (Bos taurus)
as a component of
p-SLP-76:VAV [cytosol] (Bos taurus)
p-SLP-76:ADAP [cytosol] (Bos taurus)
p-SLP-76:NCK1 [cytosol] (Bos taurus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Bos taurus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Bos taurus)
as an output of
Syk activation leads to SLP-76 activation (Bos taurus)
This entity regulates
Positively
SLP-76 stimulates PLC gamma 2
(Bos taurus)
Other forms of this molecule
LCP2 [cytosol]
Inferred From
p-Y113,128,145-LCP2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 113 (in Homo sapiens)
Coordinate
113
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 128 (in Homo sapiens)
Coordinate
128
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 145 (in Homo sapiens)
Coordinate
145
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001070312.1
OpenTargets
ENSG00000043462
Ensembl
ENSBTAT00000012345
,
ENSBTAG00000009381
,
ENSBTAP00000012345
VGNC
30818
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