Reactome | SH3KBP1 [cytosol]

SH3KBP1

Stable Identifier

R-BTA-182957

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

F1MVN9

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Signaling by the B Cell Receptor (BCR) (Bos taurus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)
        
        BLNK:GRB2:SOS1:CIN85:CBL [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Receptor Tyrosine Kinases (Bos taurus)
  - Signaling by EGFR (Bos taurus)
    - EGFR downregulation (Bos taurus)
      - Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - CBL-mediated ubiquitination of CIN85 (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - EGFR phosphorylates EPS15 (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PTPN3 dephosphorylates EPS15 (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - Sprouty sequesters CBL away from active EGFR (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
  - Signaling by MET (Bos taurus)
    - Negative regulation of MET activity (Bos taurus)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - EPS15 and HGS bind ubiquitinated MET (Bos taurus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Bos taurus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Bos taurus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Bos taurus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)

Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - Epsin family proteins bind ubiquitinated cargo (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Dissociation of clathrin-associated proteins (Bos taurus)
      - CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EGF:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
        
        CIN85:endophilin [cytosol] (Bos taurus)
        
        SH3KBP1 tetramer [cytosol] (Bos taurus)
        
        SH3KBP1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MVN9

Reference Genes

ENSEMBL:ENSBTAG00000003727

Other Identifiers

510489

DAAA02074544

ENSBTAG00000003727

ENSBTAP00000004853

ENSBTAT00000004853

EntrezGene:510489

GO:0000902

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005911

GO:0007010

GO:0008150

GO:0008360

GO:0016477

GO:0030139

GO:0031410

GO:0040011

GO:0043226

GO:0048856

GO:0048870

IPR001452

IPR011511

IPR013315

NM_001128500

NP_001121972

PF00018

PF07653

PR00452

PR01887

SH3KBP1

SM00326

UPI00005C0AAE

Participant Of

input

RELN:VLDLR:DAB1 binds SH3KBP1

hasComponent

Other forms of this molecule

Ub-SH3KBP1 [cytosol]

SH3KBP1 [plasma membrane]

Inferred From

SH3KBP1 [cytosol] (Homo sapiens)