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AP2B1 [cytosol]
Stable Identifier
R-BTA-182166
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
AP2B1, Q08DS7
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
PCP/CE pathway (Bos taurus)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Bos taurus)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Bos taurus)
clathrin:AP-2 [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
WNT5A-dependent internalization of FZD4 (Bos taurus)
WNT5A:FZD4 is endocytosed (Bos taurus)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Bos taurus)
clathrin:AP-2 [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Bos taurus)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Bos taurus)
clathrin:AP-2 [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
clathrin:AP-2 [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
AP-2 directly binds some endocytic cargo (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
AP2:chlorpromazine [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
AP2 binds chlorpromazine (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
AP2:chlorpromazine [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
RAB5 and GAPVD1 bind AP-2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Clathrin-coated vesicle [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
Recruitment of AP-2 complex and clathrin (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
AP-2:cargo [plasma membrane] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP2B1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q08DS7
Gene Names
AP2B1
Reference Genes
BioGPS Gene:282183 AP2B1
ENSEMBL:ENSBTAG00000020316
KEGG:bta:282183 AP2B1
Monarch:282183 AP2B1
NCBI Gene:282183 AP2B1
UCSC:Q08DS7 AP2B1
Reference Transcript
RefSeq:XM_024979623.2 AP2B1
RefSeq:NM_001075125.2 AP2B1
RefSeq:XM_024979621.2 AP2B1
RefSeq:XM_059877727.1 AP2B1
RefSeq:XM_024979622.2 AP2B1
Other Identifiers
282183
Bt.13163.1.S1_at
Bt.3175.1.S1_at
GO:0001822
GO:0003279
GO:0003281
GO:0005515
GO:0005737
GO:0006886
GO:0007507
GO:0012505
GO:0015031
GO:0016020
GO:0016192
GO:0030117
GO:0030122
GO:0030131
GO:0030276
GO:0035904
GO:0045202
GO:0048488
GO:0048856
GO:0060976
GO:0072583
GO:0098884
GO:0098978
Participates
as a component of
p-T156 AP-2 Complex [cytosol] (Bos taurus)
AP-2 Complex [cytosol] (Bos taurus)
Other forms of this molecule
AP2B1 [endolysosome membrane]
AP2B1 [endocytic vesicle membrane]
AP2B1 [plasma membrane]
AP2B1 [clathrin-coated endocytic vesicle membrane]
Inferred From
AP2B1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_059733710.1
,
NP_001068593.1
,
XP_024835391.1
,
XP_024835390.1
,
XP_024835389.1
ENSEMBL
ENSBTAT00000076585
,
ENSBTAG00000020316
,
ENSBTAP00000060816
VGNC
55033
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