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phospho-p-Y,Y877-ERBB2 [plasma membrane]
Stable Identifier
R-BTA-1810446
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
F1MCQ7
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
ERBB2 Activates PTK6 Signaling (Bos taurus)
Activated ERBB2 binds PTK6 (BRK) (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
ERBB2 promotes PTK6 autophosphorylation (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
Downregulation of ERBB2 signaling (Bos taurus)
Downregulation of ERBB2:ERBB3 signaling (Bos taurus)
RNF41 binds neuregulin-activated ERBB3 (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
RNF41 ubiquitinates activated ERBB3 (Bos taurus)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:MATK [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)
Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Bos taurus)
Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
ERBB2 Activates PTK6 Signaling (Bos taurus)
Activated ERBB2 binds PTK6 (BRK) (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
ERBB2 promotes PTK6 autophosphorylation (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
ERBB2 Regulates Cell Motility (Bos taurus)
MEMO1 binds RHOA:GTP:DIAPH1 (Bos taurus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
GRB7 events in ERBB2 signaling (Bos taurus)
GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
SHC1 events in ERBB2 signaling (Bos taurus)
SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
p-ERBB2 heterodimers [plasma membrane] (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
phospho-p-Y,Y877-ERBB2 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MCQ7
Reference Genes
ENSEMBL:ENSBTAG00000021798.6
UCSC:F1MCQ7
Other Identifiers
505709
Bt.9049.1.S1_at
GO:0000166
GO:0001042
GO:0002116
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005102
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006355
GO:0006468
GO:0007165
GO:0007166
GO:0007169
GO:0007173
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008045
GO:0008283
GO:0009925
GO:0010008
GO:0010628
GO:0014044
GO:0015026
GO:0016020
GO:0016301
GO:0016323
GO:0016324
GO:0016740
GO:0019838
GO:0030154
GO:0030182
GO:0030307
GO:0030971
GO:0031410
GO:0031594
GO:0032587
GO:0032886
GO:0033080
GO:0033088
GO:0034330
GO:0035025
GO:0035556
GO:0038128
GO:0038133
GO:0038134
GO:0038135
GO:0038143
GO:0042060
GO:0042127
GO:0042552
GO:0042734
GO:0042802
GO:0042995
GO:0043066
GO:0043125
GO:0043209
GO:0043235
GO:0043410
GO:0043491
GO:0045727
GO:0045785
GO:0045943
GO:0046982
GO:0048471
GO:0048709
GO:0048856
GO:0050679
GO:0070372
GO:0071363
GO:0071364
GO:0071526
GO:0090314
GO:0099645
GO:0140096
GO:1902533
Participates
as a component of
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Bos taurus)
Other forms of this molecule
phospho-p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
phospho-p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
ERBB2 [plasma membrane]
phospho-p-Y877-ERBB2 [plasma membrane]
phospho-p-Y-ERBB2 [plasma membrane]
phospho-p-6Y-ERBB2 [plasma membrane]
phospho-p-7Y-ERBB2 [plasma membrane]
Inferred From
p-Y,Y877-ERBB2 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 877 (in Homo sapiens)
Coordinate
877
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENSBTAP00000029056
,
ENSBTAT00000029056
,
ENSBTAG00000021798
VGNC
28563
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