Reactome | CD86 [plasma membrane]

CD86 [plasma membrane]

Stable Identifier

R-BTA-179784

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

CD86, A0A3Q1MLL9

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Intracellular signaling by second messengers (Bos taurus)
  - PIP3 activates AKT signaling (Bos taurus)
    - Negative regulation of the PI3K/AKT network (Bos taurus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
        
        PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        Activator:PI3K [plasma membrane] (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Bos taurus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Bos taurus)
        
        CD86 [plasma membrane] (Bos taurus)
    - PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
      - Activator:PI3K [plasma membrane] (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Bos taurus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Bos taurus)
        
        CD86 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1MLL9

Gene Names

CD86

Reference Genes

ENSEMBL:ENSBTAG00000013118.6

Other Identifiers

414345

GO:0002376

GO:0005886

GO:0006955

GO:0007155

GO:0007166

GO:0009897

GO:0016020

GO:0023052

GO:0031295

GO:0042102

GO:0071222

Participates

as an input of

CD28 homodimer binds B7-2 monomer (Bos taurus)

as a component of

CD28:B7-2 [plasma membrane] (Bos taurus)

as a member of

B7-1 homodimer/ B7-2 [plasma membrane] (Bos taurus)

Inferred From

CD86 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000114013

Ensembl

ENSBTAG00000013118, ENSBTAP00000071927, ENSBTAT00000081673

VGNC

27051

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