Reactome | PSMD12 [nucleoplasm]

PSMD12 [nucleoplasm]

Stable Identifier

R-BTA-174339

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

PSMD12, Q2KJ25

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - G1/S DNA Damage Checkpoints (Bos taurus)
    - p53-Independent G1/S DNA Damage Checkpoint (Bos taurus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Bos taurus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)
- Cell Cycle, Mitotic (Bos taurus)
  - Mitotic G1 phase and G1/S transition (Bos taurus)
    - G1/S Transition (Bos taurus)
      - Cyclin E associated events during G1/S transition (Bos taurus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)
  - Regulation of mitotic cell cycle (Bos taurus)
    - APC/C-mediated degradation of cell cycle proteins (Bos taurus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Bos taurus)
        
        Degradation of multiubiquitinated Cdh1 (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)
  - S Phase (Bos taurus)
    - Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)

Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular response to chemical stress (Bos taurus)
    - KEAP1-NFE2L2 pathway (Bos taurus)
      - Nuclear events mediated by NFE2L2 (Bos taurus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Bos taurus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)

DNA Replication (Bos taurus)

- DNA Replication Pre-Initiation (Bos taurus)
  - Assembly of the pre-replicative complex (Bos taurus)
    - Ubiquitinated geminin is degraded by the proteasome (Bos taurus)
      - 26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional regulation by RUNX2 (Bos taurus)
      - Regulation of RUNX2 expression and activity (Bos taurus)
        
        26S proteasome degrades PolyUb-RUNX2 (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)
    - Transcriptional regulation by RUNX3 (Bos taurus)
      - Regulation of RUNX3 expression and activity (Bos taurus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)
        
        26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Hedgehog (Bos taurus)
  - Hedgehog 'on' state (Bos taurus)
    - GLI2,3 are degraded by the proteasome (Bos taurus)
      - 26S proteasome [nucleoplasm] (Bos taurus)
        
        19S regulatory particle [nucleoplasm] (Bos taurus)
        
        19S RP lid [nucleoplasm] (Bos taurus)
        
        19S RP lid particle 2 [nucleoplasm] (Bos taurus)
        
        19S RP Lid Module 1 [nucleoplasm] (Bos taurus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)
        
        PSMD12 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q2KJ25 PSMD12

Gene Names

PSMD12

Chain

initiator methionine:1, chain:2-456

Reference Genes

BioGPS Gene:538204 PSMD12

KEGG:bta:538204 PSMD12

Monarch:538204 PSMD12

NCBI Gene:538204 PSMD12

UCSC:Q2KJ25 PSMD12

Reference Transcript

RefSeq:NM_001046428.1 PSMD12

Participates

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Bos taurus)

Other forms of this molecule

PSMD12 [secretory granule lumen]

PSMD12 [extracellular region]

PSMD12 [ficolin-1-rich granule lumen]

bPSMD12 [cytosol]

Inferred From

PSMD12 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001039893.1

VGNC

33463

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