Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane]
Stable Identifier
R-BTA-170849
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
O46680
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Activated type I receptor phosphorylates SMAD2/3 directly (Bos taurus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
Degradation of TGF-beta receptor complex (Bos taurus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Bos taurus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Bos taurus)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Bos taurus)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
Phosphorylated SMAD2/3 dissociates from TGFBR (Bos taurus)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGFBR2 phosphorylates TGFBR1 (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Bos taurus)
Disassembly of tight junctions (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
SMURF1 binds phosphorylated PARD6A (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
SMURF1 ubiquitinates RHOA (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Bos taurus)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Bos taurus)
p-TGFBR1 [plasma membrane] (Bos taurus)
phospho-p-4S,T185,T186-TGFBR1 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:O46680
Reference Genes
BioGPS Gene:282382
ENSEMBL:ENSBTAG00000018035
KEGG:bta:282382
Monarch:282382
NCBI Gene:282382
UCSC:O46680
Reference Transcript
RefSeq:NM_174621.2
Other Identifiers
282382
Bt.28.1.S1_at
Bt.6275.1.S1_at
GO:0000166
GO:0001501
GO:0001525
GO:0001701
GO:0001822
GO:0001824
GO:0001837
GO:0001935
GO:0001937
GO:0002088
GO:0003222
GO:0003223
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005025
GO:0005102
GO:0005114
GO:0005524
GO:0005634
GO:0005654
GO:0005768
GO:0005886
GO:0005923
GO:0005929
GO:0006355
GO:0006468
GO:0006915
GO:0007165
GO:0007178
GO:0007179
GO:0007507
GO:0008284
GO:0008354
GO:0008584
GO:0009791
GO:0009952
GO:0009986
GO:0010468
GO:0010628
GO:0010718
GO:0016020
GO:0016301
GO:0016740
GO:0019838
GO:0030154
GO:0030198
GO:0030199
GO:0030307
GO:0030335
GO:0030336
GO:0031396
GO:0031625
GO:0032331
GO:0036446
GO:0043065
GO:0043066
GO:0043226
GO:0043235
GO:0043542
GO:0045121
GO:0045893
GO:0046332
GO:0046847
GO:0046872
GO:0048538
GO:0048663
GO:0048701
GO:0048705
GO:0048844
GO:0048856
GO:0048870
GO:0050431
GO:0051491
GO:0051496
GO:0051897
GO:0060017
GO:0060021
GO:0060037
GO:0060043
GO:0060391
GO:0060412
GO:0060978
GO:0060982
GO:0061450
GO:0070021
GO:0070161
GO:0070411
GO:0070723
GO:0071560
GO:0140096
GO:1901203
GO:1902462
GO:1904018
GO:1905007
GO:1905075
GO:1905223
GO:2001235
GO:2001237
Participates
as a component of
p-TGFBR1 [plasma membrane] (Bos taurus)
Other forms of this molecule
Ub-TGFBR1 [plasma membrane]
TGFBR1 [plasma membrane]
Inferred From
p-4S,T185,T186-TGFBR1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 165 (in Homo sapiens)
Coordinate
165
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 185 (in Homo sapiens)
Coordinate
185
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 186 (in Homo sapiens)
Coordinate
186
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 189 (in Homo sapiens)
Coordinate
189
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 191 (in Homo sapiens)
Coordinate
191
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_777046.1
ENSEMBL
ENSBTAP00000024010
,
ENSBTAT00000024010
,
ENSBTAG00000018035
IntEnz
2.7.11.30
VGNC
35804
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text