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phospho-PLCG1 [plasma membrane]
Stable Identifier
R-BTA-167679
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
p-4Y-PLCG1, F1MYF9
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
TCR signaling (Bos taurus)
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
p-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Translocation of PLC-gamma1 to PIP2 (Bos taurus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-4Y-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Release of p-PLCG1 (Bos taurus)
p-4Y-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-4Y-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-4Y-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Bos taurus)
p-4Y-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Role of phospholipids in phagocytosis (Bos taurus)
Phosphorylation and activation of PLCG (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
p-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Release of PLCG from FCGR (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Bos taurus)
p-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
p-PLCG [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
Active ALK phosphorylates PLCG1 (Bos taurus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR interacts with phospholipase C-gamma (Bos taurus)
Active PLC-gamma1 dissociates from EGFR (Bos taurus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
Phospholipase C-mediated cascade: FGFR1 (Bos taurus)
Activated FGFR1 phosphorylates PLCG1 (Bos taurus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Bos taurus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
Phospholipase C-mediated cascade; FGFR2 (Bos taurus)
Activated FGFR2 phosphorylates PLCG1 (Bos taurus)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
Phospholipase C-mediated cascade; FGFR3 (Bos taurus)
Activated FGFR3 phosphorylates PLCG1 (Bos taurus)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
Phospholipase C-mediated cascade; FGFR4 (Bos taurus)
Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Bos taurus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK2 (TRKB) (Bos taurus)
Activated NTRK2 signals through PLCG1 (Bos taurus)
Activated PCLG1 dissociates from NTRK2 (Bos taurus)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by NTRK3 (TRKC) (Bos taurus)
Activated NTRK3 signals through PLCG1 (Bos taurus)
Activated PCLG1 dissociates from NTRK3 (Bos taurus)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Phosphorylation of PLCgamma by PDGFR (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated cell proliferation (Bos taurus)
PLCG1 disassociates from VEGFR2 and translocate to PM (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
SFKs phosphorylate PLCG1 (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
phospho-PLCG1 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MYF9
Gene Names
PLCG1
Reference Genes
ENSEMBL:ENSBTAG00000017584.5
ENSEMBL:ENSBTAG00000017584.6 PLCG1
Other Identifiers
281987
GO:0003824
GO:0004435
GO:0005509
GO:0006629
GO:0007165
GO:0008081
GO:0009395
GO:0010634
GO:0016042
GO:0016787
GO:0023052
GO:0035556
GO:0046872
GO:0048015
GO:0048870
GO:0050896
GO:0051209
GO:0055065
GO:0055085
Participates
as a component of
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Bos taurus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
activated FGFR2:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Bos taurus)
as a member of
p-4Y-PLCG [plasma membrane] (Bos taurus)
p-PLCG [plasma membrane] (Bos taurus)
as an output of
Activated PCLG1 dissociates from NTRK3 (Bos taurus)
Activated PCLG1 dissociates from NTRK2 (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)
PLCG1 disassociates from VEGFR2 and translocate to PM (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)
Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)
Active PLC-gamma1 dissociates from EGFR (Bos taurus)
Other forms of this molecule
phospho-PLCG1 [plasma membrane]
phospho-PLCG1 [cytosol]
PLCG1 [plasma membrane]
PLCG1 [cytosol]
Inferred From
p-4Y-PLCG1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 472 (in Homo sapiens)
Coordinate
472
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 771 (in Homo sapiens)
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 783 (in Homo sapiens)
Coordinate
783
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1253 (in Homo sapiens)
Coordinate
1253
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000124181
Ensembl
ENSBTAT00000023383
,
ENSBTAP00000023383
,
ENSBTAG00000017584
VGNC
32988
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