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TBK1 [cytosol]
Stable Identifier
R-BTA-166267
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
TBK1, E1BKP4
Locations in the PathwayBrowser
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Mitophagy (Bos taurus)
PINK1-PRKN Mediated Mitophagy (Bos taurus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Bos taurus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-37 signaling (Bos taurus)
TBK1 phosphorylation (Bos taurus)
TBK1 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
STING mediated induction of host immune responses (Bos taurus)
IRF3-mediated induction of type I IFN (Bos taurus)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
STAT6-mediated induction of chemokines (Bos taurus)
STING recruits TBK1 and STAT6 (Bos taurus)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
HSP90 binds TBK1 and IRF3 (Bos taurus)
HSP90:TBK1:IRF3 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
Negative regulators of DDX58/IFIH1 signaling (Bos taurus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)
TAX1BP1:TNFAIP3:TBK1/IKBKE [cytosol] (Bos taurus)
TBK1, IKBKE [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1, IKBKE [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TBK1:TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Bos taurus)
OPTN binds TBK1 within the activated TLR4 complex (Bos taurus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Bos taurus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TBK1:TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TBK1:TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TBK1:TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1 is phosphorylated within the activated TLR4 complex (Bos taurus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Bos taurus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TBK1:TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TBK1:TBK1 [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TBK1, IKBKE [cytosol] (Bos taurus)
TBK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BKP4
Gene Names
TBK1
Reference Genes
ENSEMBL:ENSBTAG00000017401.6
UCSC:E1BKP4 TBK1
Other Identifiers
533141
GO:0002181
GO:0002218
GO:0002376
GO:0002753
GO:0003676
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0009299
GO:0010468
GO:0010508
GO:0010629
GO:0016071
GO:0016239
GO:0016740
GO:0019903
GO:0030154
GO:0031669
GO:0032479
GO:0032481
GO:0032727
GO:0032728
GO:0034142
GO:0038202
GO:0038203
GO:0042802
GO:0043123
GO:0043491
GO:0044565
GO:0045087
GO:0045944
GO:0045948
GO:0050830
GO:0051219
GO:0051897
GO:0060340
GO:0061470
GO:0061629
GO:0098542
GO:0106310
GO:0140096
GO:0140374
GO:0140896
GO:1904262
GO:1904263
GO:1904417
GO:1904515
Participates
as an input of
STING recruits TBK1 and STAT6 (Bos taurus)
TBK1 phosphorylation (Bos taurus)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
HSP90 binds TBK1 and IRF3 (Bos taurus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Bos taurus)
as a component of
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Bos taurus)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Bos taurus)
TBK1:TBK1 [cytosol] (Bos taurus)
HSP90:TBK1:IRF3 [cytosol] (Bos taurus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Bos taurus)
as a member of
TBK1, IKBKE [cytosol] (Bos taurus)
Other forms of this molecule
phospho-TBK1 [cytosol]
TBK1 [cytosol]
phospho-TBK1 [cytosol]
Inferred From
TBK1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000023134
,
ENSBTAT00000023134
,
ENSBTAG00000017401
VGNC
35656
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