Reactome | GSPT2 [cytosol]

GSPT2 [cytosol]

Stable Identifier

R-BTA-143379

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

GSPT2, A0A3Q1MH45

Locations in the PathwayBrowser

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Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        eRF3:GDP [cytosol] (Bos taurus)
        
        eRF3 [cytosol] (Bos taurus)
        
        GSPT2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1MH45

Gene Names

GSPT2

Reference Genes

BioGPS Gene:538724 GSPT2

ENSEMBL:ENSBTAG00000013311.5

KEGG:bta:538724 GSPT2

Monarch:538724 GSPT2

NCBI Gene:538724 GSPT2

UCSC:A0A3Q1MH45 GSPT2

Reference Transcript

RefSeq:NM_001205578.1 GSPT2

Other Identifiers

538724

Bt.8641.1.A1_at

GO:0003924

GO:0005525

GO:0016787

Participates

as a member of

eRF3 [cytosol] (Bos taurus)

Inferred From

GSPT2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001192507.1

ENSEMBL

ENSBTAT00000017703, ENSBTAG00000013311, ENSBTAP00000073557

VGNC

106763