Reactome | BUB3 [cytosol]

BUB3 [cytosol]

Stable Identifier

R-BTA-141416

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

BUB3, Q1JQB2

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - Mitotic Spindle Checkpoint (Bos taurus)
    - Amplification of signal from the kinetochores (Bos taurus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Bos taurus)
        
        MAD2 associates with the Mad1 kinetochore complex (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mad1 binds kinetochore (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Release of activated MAD2 from kinetochores (Bos taurus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mad1:kinetochore complex [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
        
        Binding of the MCC complex to the APC/C complex (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Formation of the MCC complex (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
- Cell Cycle, Mitotic (Bos taurus)
  - M Phase (Bos taurus)
    - Mitotic Metaphase and Anaphase (Bos taurus)
      - Mitotic Anaphase (Bos taurus)
        
        Separation of Sister Chromatids (Bos taurus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Separation of sister chromatids (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
    - Mitotic Prometaphase (Bos taurus)
      - EML4 and NUDC in mitotic spindle formation (Bos taurus)
        
        EML4 recruits NUDC to mitotic spindle (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
      - Resolution of Sister Chromatid Cohesion (Bos taurus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Kinetochore assembly (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Microtubule-bound kinetochore [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
  - Regulation of mitotic cell cycle (Bos taurus)
    - APC/C-mediated degradation of cell cycle proteins (Bos taurus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Bos taurus)
        
        APC-Cdc20 mediated degradation of Nek2A (Bos taurus)
        
        Association of Nek2A with MCC:APC/C (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Degradation of multiubiquitinated Nek2A (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Multiubiquitinated Nek2A [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Multiubiquitination of Nek2A (Bos taurus)
        
        Multiubiquitinated Nek2A [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Bos taurus)
        
        Association of Cyclin A with the APC/C (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Degradation multiubiquitinated Cyclin A (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        hBUBR1:hBUB3:MAD2* complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
      - Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
        
        Binding of the MCC complex to the APC/C complex (Bos taurus)
        
        MCC:APC/C complex [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Formation of the MCC complex (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
  - Signaling by Rho GTPases (Bos taurus)
    - RHO GTPase Effectors (Bos taurus)
      - RHO GTPases Activate Formins (Bos taurus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Bos taurus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Bos taurus)
        
        Kinetochore [cytosol] (Bos taurus)
        
        Mitotic checkpoint complex [cytosol] (Bos taurus)
        
        BUB3 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q1JQB2

Gene Names

BUB3

Reference Genes

BioGPS Gene:539594 BUB3

ENSEMBL:ENSBTAG00000017913

KEGG:bta:539594 BUB3

Monarch:539594 BUB3

NCBI Gene:539594 BUB3

UCSC:Q1JQB2 BUB3

Reference Transcript

RefSeq:NM_001076177.1 BUB3

Other Identifiers

539594

Bt.3002.1.S1_at

GO:0000776

GO:0005515

GO:0005654

GO:0008608

GO:0033597

GO:0034501

GO:0043226

GO:0051983

Participates

as a component of

as an input of

Formation of the MCC complex (Bos taurus)

Inferred From

BUB3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001069645.1

ENSEMBL

ENSBTAP00000051164, ENSBTAT00000057027, ENSBTAG00000017913

VGNC

26606

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