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What is Reactome ?
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Ub [cytosol]
Stable Identifier
R-BTA-113595
Type
Set [DefinedSet]
Species
Bos taurus
Compartment
cytosol
Synonyms
ubiquitin
Locations in the PathwayBrowser
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Aggrephagy (Bos taurus)
Aggresome dissociates from dynein and microtubule (Bos taurus)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Bos taurus)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Bos taurus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Bos taurus)
Ub:UBE2N:UBE2V1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Bos taurus)
Ub:UBE2N:UBE2V1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Parkin transfers Ub to misfolded proteins (Bos taurus)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Bos taurus)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Bos taurus)
Ub:UBE2N:UBE2V1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Bos taurus)
Ub-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Bos taurus)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Bos taurus)
PolyUb-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Bos taurus)
Ub-Misfolded Proteins [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Pexophagy (Bos taurus)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Bos taurus)
p53-Dependent G1/S DNA damage checkpoint (Bos taurus)
p53-Dependent G1 DNA Damage Response (Bos taurus)
Stabilization of p53 (Bos taurus)
Autodegradation of the E3 ubiquitin ligase COP1 (Bos taurus)
Autoubiquitination of phospho-COP1(Ser-387 ) (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Proteasome mediated degradation of COP1 (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
p53-Independent G1/S DNA damage checkpoint (Bos taurus)
p53-Independent DNA Damage Response (Bos taurus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Bos taurus)
Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-p-S124-CDC25A [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
G2/M Checkpoints (Bos taurus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)
Ub [cytosol] (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Separation of Sister Chromatids (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
Ub [cytosol] (Bos taurus)
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Bos taurus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)
Ub [cytosol] (Bos taurus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF-FBXL7 ubiquitinates AURKA (Bos taurus)
Ub [cytosol] (Bos taurus)
Regulation of PLK1 Activity at G2/M Transition (Bos taurus)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-p-S252,S497,T501-BORA [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
The role of GTSE1 in G2/M progression after G2 checkpoint (Bos taurus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)
Ub [cytosol] (Bos taurus)
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
Ub [cytosol] (Bos taurus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)
Ub [cytosol] (Bos taurus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of Cyclin B (Bos taurus)
Degradation of multiubiquitinated Cyclin B (Bos taurus)
Ub [cytosol] (Bos taurus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)
Ub [cytosol] (Bos taurus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
APC/C:Cdc20 mediated degradation of Securin (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
Ub [cytosol] (Bos taurus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Bos taurus)
APC-Cdc20 mediated degradation of Nek2A (Bos taurus)
Degradation of multiubiquitinated Nek2A (Bos taurus)
Multiubiquitinated Nek2A [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Multiubiquitination of Nek2A (Bos taurus)
Multiubiquitinated Nek2A [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Bos taurus)
Degradation multiubiquitinated Cyclin A (Bos taurus)
Ub [cytosol] (Bos taurus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)
Ub [cytosol] (Bos taurus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
SCF-beta-TrCP mediated degradation of Emi1 (Bos taurus)
Ubiquitination of Emi1 by SCF-beta-TrCP (Bos taurus)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
S Phase (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated Cdc6 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated Cdc6 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitin-dependent degradation of Cyclin D (Bos taurus)
Proteasome mediated degradation of Cyclin D1 (Bos taurus)
Ub [cytosol] (Bos taurus)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
26S proteasome degrades Ub-NFE2L2 (Bos taurus)
Ub [cytosol] (Bos taurus)
CUL3:RBX1 ubiquitinates KEAP1 (Bos taurus)
Ub [cytosol] (Bos taurus)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Bos taurus)
Ub [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)
Ub [cytosol] (Bos taurus)
MUL1 ubiquitinates UBXN7 (Bos taurus)
Ub [cytosol] (Bos taurus)
TRIM21 ubiquitinates SQSTM1 (Bos taurus)
Ub [cytosol] (Bos taurus)
ub UBXN7 is degraded by the 26S proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
UBE2D1,2,3:Ubiquitin [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
Ub [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
DNA Replication (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated Cdc6 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated Cdc6 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Orc1 removal from chromatin (Bos taurus)
Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
Signaling by ROBO receptors (Bos taurus)
Regulation of expression of SLITs and ROBOs (Bos taurus)
USP33 deubiquitinates ROBO1 (Bos taurus)
Ub [cytosol] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
Ub [cytosol] (Bos taurus)
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Bos taurus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)
Ub [cytosol] (Bos taurus)
ITCH polyubiquitinates TP73 (Bos taurus)
Ub [cytosol] (Bos taurus)
Transcriptional regulation by RUNX2 (Bos taurus)
Regulation of RUNX2 expression and activity (Bos taurus)
STUB1 polyubiquitinates RUNX2 (Bos taurus)
Ub [cytosol] (Bos taurus)
Transcriptional regulation by RUNX3 (Bos taurus)
Regulation of RUNX3 expression and activity (Bos taurus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
E1 mediated ubiquitin activation (Bos taurus)
E1 bound ubiquitin [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
Ub:substrate [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Proteasomal cleavage of substrate (Bos taurus)
Ub [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
Ub:substrate [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Transfer of ubiquitin from E1 to E2 (Bos taurus)
E1 bound ubiquitin [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of NF-kappaB in B cells (Bos taurus)
SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)
Ub [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Negative regulation of FLT3 (Bos taurus)
Ubiquitination of FLT3 (Bos taurus)
Ub [cytosol] (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Recruitment of STAT2 to p-IFNAR1 (Bos taurus)
multiubiquitinated STAT2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by CSF3 (G-CSF) (Bos taurus)
Inactivation of CSF3 (G-CSF) signaling (Bos taurus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Bos taurus)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
Ub [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Alpha-protein kinase 1 signaling pathway (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)
Ub [cytosol] (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
Ub [cytosol] (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
Regulation of innate immune responses to cytosolic DNA (Bos taurus)
DDX41 ubiquitination by TRIM21 (Bos taurus)
Ub [cytosol] (Bos taurus)
STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)
Ub [cytosol] (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
Negative regulators of DDX58/IFIH1 signaling (Bos taurus)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Bos taurus)
Auto-ubiquitination of TRAF3 (Bos taurus)
Ub [cytosol] (Bos taurus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Bos taurus)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Bos taurus)
Ub [cytosol] (Bos taurus)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
Ub [cytosol] (Bos taurus)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
Ub [cytosol] (Bos taurus)
IKK complex recruitment mediated by RIP1 (Bos taurus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)
RIP1 ubiqutin ligases [cytosol] (Bos taurus)
c-IAP1:UBE2D [cytosol] (Bos taurus)
UBE2D1,2,3:Ubiquitin [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
c-IAP2:UBE2D [cytosol] (Bos taurus)
UBE2D1,2,3:Ubiquitin [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)
Ub [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
Ub [cytosol] (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)
Ub [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
Ub [cytosol] (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
Regulation of pyruvate metabolism (Bos taurus)
CTLH E3 ligase ubiquitinates LDHA (Bos taurus)
Ub [cytosol] (Bos taurus)
CTLH E3 ligase ubiquitinates PKM-1 (Bos taurus)
Ub [cytosol] (Bos taurus)
Metabolism of RNA (Bos taurus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Bos taurus)
AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)
Ub [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Bos taurus)
Calnexin/calreticulin cycle (Bos taurus)
ER Quality Control Compartment (ERQC) (Bos taurus)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Bos taurus)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Bos taurus)
Ub [cytosol] (Bos taurus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
OTUD7A hydrolyses K11diUb (Bos taurus)
Ub [cytosol] (Bos taurus)
UCH proteinases (Bos taurus)
UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)
UCHL1,UCHL3:Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-specific processing proteases (Bos taurus)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)
Ub [cytosol] (Bos taurus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
USP5 cleaves polyubiquitin (Bos taurus)
USP5:Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
USP8 deubiquitinates STAM2:HGS (Bos taurus)
Ub [cytosol] (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
Ub [cytosol] (Bos taurus)
Neddylation (Bos taurus)
26S proteasome degrades HIFalpha (Bos taurus)
Ub [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
26S proteasome degrades Ub-NFE2L2 (Bos taurus)
Ub [cytosol] (Bos taurus)
CUL9:RBX1 ubiquitinates BIRC5 (Bos taurus)
Ub [cytosol] (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)
Ub [cytosol] (Bos taurus)
MUL1 ubiquitinates UBXN7 (Bos taurus)
Ub [cytosol] (Bos taurus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)
UBE2D1,2,3:Ubiquitin [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
ub UBXN7 is degraded by the 26S proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Protein ubiquitination (Bos taurus)
E3 ubiquitin ligases ubiquitinate target proteins (Bos taurus)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Bos taurus)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Bos taurus)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Bos taurus)
RNF144A:PRKDC:Ub:UBE2L3 [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF144A polyubiquitinates PRKDC (Bos taurus)
RNF144A:PRKDC:Ub:UBE2L3 [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Bos taurus)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Bos taurus)
Ub:UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF152 polyubiquitinates RRAGA (Bos taurus)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Bos taurus)
Ub:UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF181 binds BCL10 and Ubiquitin:E2 (Bos taurus)
RNF181:BCL10:Ub:E2 [cytoplasm] (Bos taurus)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF181 polyubiquinates BCL10 (Bos taurus)
RNF181:BCL10:Ub:E2 [cytoplasm] (Bos taurus)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Bos taurus)
UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
Ub [cytosol] (Bos taurus)
UBA1 conjugates ubiquitin to UBA1 in the cytosol (Bos taurus)
Ub-Cys632-UBA1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Bos taurus)
Ub-Cys632-UBA1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:E2 (UBA1 substrate) [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)
Ub-Cys625-UBA6:ubiquitin adenylate [cytosol] (Bos taurus)
Ub-Cys625-UBA6 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:E2 (UBA6 substrate) [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Cys632-UBA1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Bos taurus)
Ub-Cys632-UBA1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
ITCH polyubiquitinates MLKL at K50 (Bos taurus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MLKL binds ITCH (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PRKN polyubiquitinates RIPK3 (Bos taurus)
RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RIPK3 binds p-S9-PRKN (Bos taurus)
RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
STUB1 ubiquitinates RIPK3 at K55, K363 (Bos taurus)
Ub [cytosol] (Bos taurus)
Protein localization (Bos taurus)
Peroxisomal protein import (Bos taurus)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:PEX5L [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Bos taurus)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Bos taurus)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Bos taurus)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Bos taurus)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Bos taurus)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
USP9X binds Ub:PEX5L (Bos taurus)
USP9X:Ub:PEX5L [cytosol] (Bos taurus)
Ub:PEX5L [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:PEX5L [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)
USP9X:Ub:PEX5L [cytosol] (Bos taurus)
Ub:PEX5L [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
Ub [cytosol] (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
Ub [cytosol] (Bos taurus)
K63polyUb-RIPK1 is deubiquitinated (Bos taurus)
Ub [cytosol] (Bos taurus)
LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MIB2 binds CFLAR (Bos taurus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Bos taurus)
Ub:UBE2D1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MIB2 binds CYLD (Bos taurus)
MIB2:CYLD:UBE2D2 [cytosol] (Bos taurus)
Ub:UBE2D2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
Ub:UBE2D1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MIB2 ubiquitinates CFLAR (Bos taurus)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Bos taurus)
Ub:UBE2D1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)
MIB2:CYLD:UBE2D2 [cytosol] (Bos taurus)
Ub:UBE2D2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
Ub:UBE2D1 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RIPK1 binds STUB1 (Bos taurus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Bos taurus)
Ub:UBE2D3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:UBE2D3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Bos taurus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Bos taurus)
Ub:UBE2D3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRIF signals cell death from the nucleus (Bos taurus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)
Ubiquitinated NRIF [cytosol] (Bos taurus)
K63 linked polyubiquitin chain [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Bos taurus)
K63 linked polyubiquitin chain [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Bos taurus)
K63 linked polyubiquitin chain [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
TRAF6 polyubiquitinates NRIF (Bos taurus)
K63 linked polyubiquitin chain [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated NRIF [cytosol] (Bos taurus)
K63 linked polyubiquitin chain [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
p75NTR signals via NF-kB (Bos taurus)
NF-kB is activated and signals survival (Bos taurus)
IkB is ubiquitinated and degraded (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated phospho-IkB [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
p75NTR recruits signalling complexes (Bos taurus)
TRAF6 is auto-ubiquitinated (Bos taurus)
Ub [cytosol] (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN localization (Bos taurus)
PTEN undergoes monoubiquitination (Bos taurus)
Ub [cytosol] (Bos taurus)
Regulation of PTEN stability and activity (Bos taurus)
MKRN1 polyubiquitinates PTEN (Bos taurus)
Ub [cytosol] (Bos taurus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)
Ub [cytosol] (Bos taurus)
Proteasome degrades polyubiquitinated PTEN (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF146 polyubiquitinates PARylated PTEN (Bos taurus)
Ub [cytosol] (Bos taurus)
TRIM27 polyubiquitinates PTEN (Bos taurus)
Ub [cytosol] (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
Ub [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
BRAP autoubiquitinates (Bos taurus)
Ub [cytosol] (Bos taurus)
MAPK6/MAPK4 signaling (Bos taurus)
MAPK6 is degraded by the 26S proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
Degradation of GLI1 by the proteasome (Bos taurus)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)
Ub [cytosol] (Bos taurus)
GLI3 is processed to GLI3R by the proteasome (Bos taurus)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)
Ub [cytosol] (Bos taurus)
Hedgehog 'on' state (Bos taurus)
NUMB:ITCH ubiquitinates GLI1 (Bos taurus)
Ub [cytosol] (Bos taurus)
ub-GLI is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Hedgehog ligand biogenesis (Bos taurus)
Hh C-terminal fragments are degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by NOTCH (Bos taurus)
Signaling by NOTCH1 (Bos taurus)
Activated NOTCH1 Transmits Signal to the Nucleus (Bos taurus)
ITCH ubiquitinates DTX (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-DTX:ITCH [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Bos taurus)
CBL autoubiquitinates (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
CBL ubiquitinates Sprouty (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
CBL-mediated ubiquitination of CIN85 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitination of stimulated EGFR (CBL) (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by ERBB2 (Bos taurus)
Downregulation of ERBB2 signaling (Bos taurus)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
CUL5 mediates ubiquitination of ERBB2 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Downregulation of ERBB2:ERBB3 signaling (Bos taurus)
Deubiquitination of RNF41 by P-USP8 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-RNF41:p-USP8 [cytosol] (Bos taurus)
Ub-RNF41 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF41 ubiquitinates ERBB3 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-ERBB3 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF41 ubiquitinates activated ERBB3 (Bos taurus)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Self-ubiquitination of RNF41 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-RNF41 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated RNF41 binds P-USP8 (Bos taurus)
Ub-RNF41 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-RNF41:p-USP8 [cytosol] (Bos taurus)
Ub-RNF41 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by ERBB4 (Bos taurus)
Downregulation of ERBB4 signaling (Bos taurus)
ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by MET (Bos taurus)
Negative regulation of MET activity (Bos taurus)
CBL monoubiquitinates activated MET (Bos taurus)
Ub [cytosol] (Bos taurus)
USP8 deubiquitinates LRIG1 (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
Degradation of TGF-beta receptor complex (Bos taurus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Degradation of ubiquitinated SMAD2 (Bos taurus)
Ub-SMAD2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Degradation of ubiquitinated SMAD3 (Bos taurus)
Ub-SMAD3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
SMURF2 ubiquitinates SMAD2 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-SMAD2 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
STUB1 (CHIP) ubiquitinates SMAD3 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-SMAD3 [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Bos taurus)
Disassembly of tight junctions (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Bos taurus)
Ub [cytosol] (Bos taurus)
SMURF1 ubiquitinates RHOA (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
Ub [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
PCP/CE pathway (Bos taurus)
Asymmetric localization of PCP proteins (Bos taurus)
SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)
Ub [cytosol] (Bos taurus)
Degradation of beta-catenin by the destruction complex (Bos taurus)
Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Degradation of AXIN (Bos taurus)
AXIN is ubiquitinated by SMURF2 (Bos taurus)
Ub [cytosol] (Bos taurus)
RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-RibC-AXIN is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Degradation of DVL (Bos taurus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Bos taurus)
Ub [cytosol] (Bos taurus)
DVL1 is ubiquitinated by HECW1 (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated DVL is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Regulation of FZD by ubiquitination (Bos taurus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)
Ub [cytosol] (Bos taurus)
ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)
Ub [cytosol] (Bos taurus)
ZNRF3 ubiquitinates FZD to promote its downregulation (Bos taurus)
Ub [cytosol] (Bos taurus)
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
Ub [cytosol] (Bos taurus)
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
misfolded CFTR is degraded by the 26S proteasome (Bos taurus)
Ub [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub [cytosol] (Bos taurus)
Iron uptake and transport (Bos taurus)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)
Ub [cytosol] (Bos taurus)
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
Epsin family proteins bind ubiquitinated cargo (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
RAB5 and GAPVD1 bind AP-2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
Ub [cytosol] (Bos taurus)
Participants
members
RPS27A [cytosol]
(Bos taurus)
UBA52 [cytosol]
(Bos taurus)
UBB [cytosol]
(Bos taurus)
UBC [cytosol]
(Bos taurus)
Participates
as a component of
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
Ub:PEX5L [cytosol] (Bos taurus)
USP5:Ub [cytosol] (Bos taurus)
UCHL1,UCHL3:Ub [cytosol] (Bos taurus)
Ub:E2 (UBA6 substrate) [cytosol] (Bos taurus)
Ub-Cys625-UBA6 [cytosol] (Bos taurus)
Ub:E2 (UBA1 substrate) [cytosol] (Bos taurus)
Ub-Cys632-UBA1 [cytosol] (Bos taurus)
Ub:PEX5L [peroxisomal membrane] (Bos taurus)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Bos taurus)
Ub:UBE2N [cytosol] (Bos taurus)
Ub:UBE2D1,2,3 [cytosol] (Bos taurus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub-DTX:ITCH [cytosol] (Bos taurus)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Bos taurus)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Bos taurus)
ub-hydroxyPro-HIF-alpha [cytosol] (Bos taurus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub:UBE2D1 [cytosol] (Bos taurus)
Ub:UBE2D2 [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
Ub-p-S124-CDC25A [cytosol] (Bos taurus)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Bos taurus)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Bos taurus)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Bos taurus)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Bos taurus)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Bos taurus)
ubiquitinated Cdc6 [cytosol] (Bos taurus)
Ub-p-S252,S497,T501-BORA [cytosol] (Bos taurus)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Bos taurus)
K63 linked polyubiquitin chain [cytosol] (Bos taurus)
Ubiquitinated phospho-IkB [cytosol] (Bos taurus)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Bos taurus)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Bos taurus)
Ub-ERBB3 [plasma membrane] (Bos taurus)
Ub-RNF41 [cytosol] (Bos taurus)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Bos taurus)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Bos taurus)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Bos taurus)
Ub:UBE2L3 [cytosol] (Bos taurus)
Ub:UBE2D3 [cytosol] (Bos taurus)
UBE2D1,2,3:Ubiquitin [cytosol] (Bos taurus)
multiubiquitinated STAT2 [cytosol] (Bos taurus)
Ub-misfolded nascent CFTR [cytosol] (Bos taurus)
Ub:UBE2N:UBE2V1 [cytosol] (Bos taurus)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Bos taurus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
Multiubiquitinated Nek2A [cytosol] (Bos taurus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
Ub-SMAD3 [cytosol] (Bos taurus)
Ub-SMAD2 [cytosol] (Bos taurus)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Bos taurus)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Bos taurus)
Ub:substrate [cytosol] (Bos taurus)
Ubiquitin:E2 conjugating enzymes [cytosol] (Bos taurus)
E1 bound ubiquitin [cytosol] (Bos taurus)
as an input of
AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)
CUL9:RBX1 ubiquitinates BIRC5 (Bos taurus)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
UBA1 adenylates ubiquitin in the cytosol (Bos taurus)
SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)
Ubiquitination of FLT3 (Bos taurus)
TRIM21 ubiquitinates SQSTM1 (Bos taurus)
MUL1 ubiquitinates UBXN7 (Bos taurus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)
CUL3:RBX1 ubiquitinates KEAP1 (Bos taurus)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Bos taurus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)
CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)
CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)
ITCH polyubiquitinates TP73 (Bos taurus)
NUMB:ITCH ubiquitinates GLI1 (Bos taurus)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)
STUB1 polyubiquitinates RUNX2 (Bos taurus)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)
ITCH ubiquitinates DTX (Bos taurus)
DDX41 ubiquitination by TRIM21 (Bos taurus)
STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)
CTLH E3 ligase ubiquitinates LDHA (Bos taurus)
CTLH E3 ligase ubiquitinates PKM-1 (Bos taurus)
CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)
AXIN is ubiquitinated by SMURF2 (Bos taurus)
RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)
SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Bos taurus)
DVL1 is ubiquitinated by HECW1 (Bos taurus)
ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)
ZNRF3 ubiquitinates FZD to promote its downregulation (Bos taurus)
Autoubiquitination of phospho-COP1(Ser-387 ) (Bos taurus)
CBL ubiquitinates Sprouty (Bos taurus)
CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)
CBL-mediated ubiquitination of CIN85 (Bos taurus)
Ubiquitination of stimulated EGFR (CBL) (Bos taurus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)
SCF-FBXL7 ubiquitinates AURKA (Bos taurus)
SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)
CBL autoubiquitinates (Bos taurus)
IkB is ubiquitinated and degraded (Bos taurus)
TRAF6 is auto-ubiquitinated (Bos taurus)
CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
CUL5 mediates ubiquitination of ERBB2 (Bos taurus)
RNF41 ubiquitinates ERBB3 (Bos taurus)
RNF41 ubiquitinates activated ERBB3 (Bos taurus)
Self-ubiquitination of RNF41 (Bos taurus)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)
ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)
CBL monoubiquitinates activated MET (Bos taurus)
BRAP autoubiquitinates (Bos taurus)
SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)
MKRN1 polyubiquitinates PTEN (Bos taurus)
RNF146 polyubiquitinates PARylated PTEN (Bos taurus)
TRIM27 polyubiquitinates PTEN (Bos taurus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)
PTEN undergoes monoubiquitination (Bos taurus)
STUB1 ubiquitinates RIPK3 at K55, K363 (Bos taurus)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Bos taurus)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
Auto-ubiquitination of TRAF3 (Bos taurus)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Bos taurus)
Ubiquitination of Emi1 by SCF-beta-TrCP (Bos taurus)
Multiubiquitination of Nek2A (Bos taurus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)
STUB1 (CHIP) ubiquitinates SMAD3 (Bos taurus)
SMURF2 ubiquitinates SMAD2 (Bos taurus)
SMURF1 ubiquitinates RHOA (Bos taurus)
E1 mediated ubiquitin activation (Bos taurus)
as an output of
MAPK6 is degraded by the 26S proteasome (Bos taurus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)
OTUD7A hydrolyses K11diUb (Bos taurus)
USP5 cleaves polyubiquitin (Bos taurus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
USP8 deubiquitinates STAM2:HGS (Bos taurus)
26S proteasome degrades HIFalpha (Bos taurus)
Hh C-terminal fragments are degraded by the proteasome (Bos taurus)
USP33 deubiquitinates ROBO1 (Bos taurus)
ub UBXN7 is degraded by the 26S proteasome (Bos taurus)
misfolded CFTR is degraded by the 26S proteasome (Bos taurus)
26S proteasome degrades Ub-NFE2L2 (Bos taurus)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)
ub-GLI is degraded by the proteasome (Bos taurus)
Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
K63polyUb-RIPK1 is deubiquitinated (Bos taurus)
Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)
Ub-RibC-AXIN is degraded by the proteasome (Bos taurus)
Ubiquitinated DVL is degraded by the proteasome (Bos taurus)
Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)
Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)
Proteasome mediated degradation of COP1 (Bos taurus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)
Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)
Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)
Proteasome mediated degradation of Cyclin D1 (Bos taurus)
Deubiquitination of RNF41 by P-USP8 (Bos taurus)
USP8 deubiquitinates LRIG1 (Bos taurus)
Proteasome degrades polyubiquitinated PTEN (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)
Proteasomal cleavage of substrate (Bos taurus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
Degradation multiubiquitinated Cyclin A (Bos taurus)
Degradation of multiubiquitinated Cyclin B (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
Degradation of multiubiquitinated Nek2A (Bos taurus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)
Inferred From
Ub [cytosol]
(Homo sapiens)
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