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CBL [cytosol]
Stable Identifier
R-BTA-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
CBL, A0A3Q1LN00
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Negative regulation of FLT3 (Bos taurus)
Active FLT3 binds to CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
active FLT3:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
FLT3 phosphorylates CBL (Bos taurus)
active FLT3:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
CBL [cytosol] (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
PTPN11 binds CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Bos taurus)
PTK6 phosphorylates CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
Binding of CBL to EGFR (Bos taurus)
CBL [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL binds to GRB2 (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL ubiquitinates Sprouty (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL-mediated ubiquitination of CIN85 (Bos taurus)
CBL [cytosol] (Bos taurus)
CDC42:GTP binds CBL:Beta-Pix (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
Localization of CBL:GRB2 to the membrane (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
Phosphorylation of CBL (EGFR:CBL) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
Sprouty lures CBL away from EGFR (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL:SPRY1/2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
CBL [cytosol] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by MET (Bos taurus)
Negative regulation of MET activity (Bos taurus)
CBL binds MET (Bos taurus)
CBL:GRB2,CBL [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Bos taurus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
MET phosphorylates CBL (Bos taurus)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Bos taurus)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
CBL [cytosol] (Bos taurus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Regulation of KIT signaling (Bos taurus)
Recruitment of CBL to KIT (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
CBL binds TGFBR2 (Bos taurus)
CBL [cytosol] (Bos taurus)
TGFBR2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
CBL neddylates TGFBR2 (Bos taurus)
CBL [cytosol] (Bos taurus)
TGFBR2:CBL [plasma membrane] (Bos taurus)
CBL [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1LN00
Gene Names
CBL
Reference Genes
BioGPS Gene:527418 CBL
ENSEMBL:ENSBTAG00000006817.6
KEGG:bta:527418 CBL
Monarch:527418 CBL
NCBI Gene:527418 CBL
UCSC:A0A3Q1LN00 CBL
Reference Transcript
RefSeq:XM_002693082.6 CBL
Other Identifiers
527418
GO:0001784
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005794
GO:0005829
GO:0005886
GO:0005929
GO:0006511
GO:0007166
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0023051
GO:0032487
GO:0042059
GO:0043066
GO:0043226
GO:0046872
GO:0046875
GO:0048260
GO:0051897
GO:0061630
GO:0070086
GO:0140096
GO:2000583
Participates
as an input of
Active FLT3 binds to CBL (Bos taurus)
Recruitment of CBL to KIT (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
PTPN11 binds CBL (Bos taurus)
SPRY2 binds CBL (Bos taurus)
CDC42:GTP binds CBL:Beta-Pix (Bos taurus)
Sprouty lures CBL away from EGFR (Bos taurus)
CBL binds to GRB2 (Bos taurus)
Binding of CBL to EGFR (Bos taurus)
PTK6 phosphorylates CBL (Bos taurus)
CBL binds TGFBR2 (Bos taurus)
as a component of
active FLT3:CBL [plasma membrane] (Bos taurus)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Bos taurus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Bos taurus)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Bos taurus)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Bos taurus)
CBL:SPRY1/2 [cytosol] (Bos taurus)
CBL:GRB2 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Bos taurus)
TGFBR2:CBL [plasma membrane] (Bos taurus)
as a candidate of
CBL:GRB2,CBL [cytosol] (Bos taurus)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)
CBL neddylates TGFBR2 (Bos taurus)
Other forms of this molecule
phospho-CBL [cytosol]
phospho-CBL [plasma membrane]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_002693128.3
ENSEMBL
ENSBTAG00000006817
,
ENSBTAP00000061310
,
ENSBTAT00000072559
VGNC
26808
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