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alvocidib [nucleoplasm]
Stable Identifier
R-ALL-9754236
Type
ChemicalDrug
Compartment
nucleoplasm
Synonyms
flavopiridol
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Mus musculus
Rattus norvegicus
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Bos taurus)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Bos taurus)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Bos taurus)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Bos taurus)
CDK4 inhibitors bind CDK4 (Bos taurus)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Bos taurus)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Bos taurus)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G1 Phase (Caenorhabditis elegans)
Cyclin D associated events in G1 (Caenorhabditis elegans)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Caenorhabditis elegans)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Caenorhabditis elegans)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Caenorhabditis elegans)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Caenorhabditis elegans)
CDK4 inhibitors bind CDK4 (Caenorhabditis elegans)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Caenorhabditis elegans)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Caenorhabditis elegans)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1 Phase (Canis familiaris)
Cyclin D associated events in G1 (Canis familiaris)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Canis familiaris)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Canis familiaris)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Canis familiaris)
CDK4 inhibitors bind CDK4 (Canis familiaris)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Canis familiaris)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Canis familiaris)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
Mitotic G1 phase and G1/S transition (Danio rerio)
G1 Phase (Danio rerio)
Cyclin D associated events in G1 (Danio rerio)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Danio rerio)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Danio rerio)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Danio rerio)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Danio rerio)
CDK4 inhibitors bind CDK4 (Danio rerio)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Danio rerio)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Danio rerio)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
G1 Phase (Dictyostelium discoideum)
Cyclin D associated events in G1 (Dictyostelium discoideum)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Dictyostelium discoideum)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Dictyostelium discoideum)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Dictyostelium discoideum)
CDK4 inhibitors bind CDK4 (Dictyostelium discoideum)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Dictyostelium discoideum)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Dictyostelium discoideum)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Drosophila melanogaster)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Drosophila melanogaster)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Drosophila melanogaster)
CDK4 inhibitors bind CDK4 (Drosophila melanogaster)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Drosophila melanogaster)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Drosophila melanogaster)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Homo sapiens)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Homo sapiens)
CDK4 inhibitors bind CDK4 (Homo sapiens)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Homo sapiens)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Homo sapiens)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G1 Phase (Mus musculus)
Cyclin D associated events in G1 (Mus musculus)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Mus musculus)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Mus musculus)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Mus musculus)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Mus musculus)
CDK4 inhibitors bind CDK4 (Mus musculus)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Mus musculus)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Mus musculus)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G1 Phase (Rattus norvegicus)
Cyclin D associated events in G1 (Rattus norvegicus)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Rattus norvegicus)
CDK4 inhibitors bind CDK4 (Rattus norvegicus)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
Mitotic G1 phase and G1/S transition (Schizosaccharomyces pombe)
G1 Phase (Schizosaccharomyces pombe)
Cyclin D associated events in G1 (Schizosaccharomyces pombe)
Drug-mediated inhibition of CDK4/CDK6 activity (Schizosaccharomyces pombe)
CDK4 inhibitors bind CDK4 (Schizosaccharomyces pombe)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Schizosaccharomyces pombe)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Schizosaccharomyces pombe)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
Mitotic G1 phase and G1/S transition (Sus scrofa)
G1 Phase (Sus scrofa)
Cyclin D associated events in G1 (Sus scrofa)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Sus scrofa)
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Sus scrofa)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Sus scrofa)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Sus scrofa)
CDK4 inhibitors bind CDK4 (Sus scrofa)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Sus scrofa)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Sus scrofa)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Cell Cycle (Xenopus tropicalis)
Cell Cycle, Mitotic (Xenopus tropicalis)
Mitotic G1 phase and G1/S transition (Xenopus tropicalis)
G1 Phase (Xenopus tropicalis)
Cyclin D associated events in G1 (Xenopus tropicalis)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Xenopus tropicalis)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
Drug-mediated inhibition of CDK4/CDK6 activity (Xenopus tropicalis)
CDK4 inhibitors bind CDK4 (Xenopus tropicalis)
CDK4 inhibitors [nucleoplasm]
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Xenopus tropicalis)
CDK4 inhibitors (CCND1) [nucleoplasm]
alvocidib [nucleoplasm]
External Reference Information
External Reference
alvocidib [Guide to Pharmacology:5680]
Participates
as a member of
CDK4 inhibitors (CCND1) [nucleoplasm]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
0004992
ChEBI
47344
PharmacoDB
PDBC02061
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